| 广州市中老年人午睡频率和睡眠时长与颈动脉粥样硬化的相关性研究 |
| 投稿时间：2024-09-06 修订日期：2024-10-13 点此下载全文 |
| 引用本文：李永琪,张维森,江朝强,靳雅丽,王娇,徐琳.广州市中老年人午睡频率和睡眠时长与颈动脉粥样硬化的相关性研究[J].医学研究杂志,2025,54(2):64-69 |
| DOI：
10.11969/j.issn.1673-548X.2025.02.011 |
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| 基金项目:国家自然科学基金资助项目(82373661) |
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| 中文摘要:目的 探讨广州市中老年人午睡频率和睡眠时长与颈动脉粥样硬化(carotid atherosclerosis,CAS)发生风险的相关性。方法 采用回顾性研究方法,选取2006年9月~2008年3月“广州生物库队列-心血管疾病亚队列”招募的1170例50岁以上的中老年人。收集受试者的一般资料,并利用彩色多普勒超声技术测量颈总动脉内膜中层厚度(intima-media thickness of common carotid artery,CCA-IMT)。采用Logistic回归分析评价午睡频率和睡眠时长与CAS发生风险的相关性。结果 在对性别、年龄、体重指数(body mass index, BMI)、腰臀比(waist-to-hip ratio, WHR)、体力活动水平、吸烟史、饮酒史以及糖尿病史等潜在混杂因素进行调整后,研究发现,与从不午睡者比较,每天午睡者患CAS的风险更高[调整后Exp(β)=2.095,95%CI:1.823~2.407,P＜0.001]。此外,本研究观察到睡眠时长与CAS患病率之间存在“U”型关联。进一步研究发现,与每天睡眠时长6h者比较,睡眠时长≤5h者、8h者和≥10h者患CAS的风险显著增加(调整后的OR=1.420,95% CI:1.117~1.805,P＜0.001；OR=1.356,95% CI:1.142~1.610,P＜0.001；OR=1.537,95% CI:1.156~2.044,P＜0.01)。结论 每天午睡以及过短或过长的睡眠时间均可能增加患CAS的风险。建议适当减少午睡频率并维持适宜的睡眠时间,以期降低CAS的发生率。 |
| 中文关键词:午睡频率 睡眠时长 CAS 广州中老年人 |
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| Correlation between Nap Frequency and Sleep Duration and Carotid Atherosclerosis in Middle-aged and Elderly People in Guangzhou. |
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| Abstract:Objective To explore the correlation between nap frequency and sleep duration and the risk of carotid atherosclerosis (CAS) in the middle-aged and elderly people in Guangzhou. Methods A retrospective study was conducted to select 1170middle-aged and elderly patients over 50 years who were enrolled in “Guangzhou Biobank Cohort-Cardiovascular Disease Subcohort” from September 2006 to March 2008. The general data of the subjects were collected, and the intima-media thickness of common carotid artery,CCA-IMT was measured by color Doppler ultrasound. Logistic regression analysis was used to evaluate the correlation between nap frequency and sleep duration and the risk of CAS. Results After adjusting for potential confounding factors such as gender, age, body mass index (BMI), waist-to-hip ratio (WHR), physical activity level, smoking, alcohol consumption, and diabetes, the study found that compared with those who never nappers, Daily nappers had a higher risk of CAS [adjusted Exp(β)=2.095,95% CI:1.823-2.407, P<0.001]. In addition, this study observed a “U-shaped” association between sleep duration and CAS prevalence. Further studies found that compared with those who slept for 6h per day, those who slept for ≤5h, 8h and ≥10h had a significantly increased risk of CAS (adjusted OR=1.420,95% CI:1.117-1.805,P<0.001; OR=1.356,95% CI:1.142-1.610,P<0.001; OR=1.537,95% CI:1.156-2.044, P<0.01). Conclusion Daily napping and short or long sleep duration may increase the risk of CAS. It is recommended to reduce the nap frequency and maintain the appropriate sleep duration in order to reduce the incidence of CAS. |
| keywords:Nap frequency Sleep duration Carotid atherosclerosis Middle-aged and elderly people in Guangzhou |
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