| 单核细胞与高密度脂蛋白胆固醇比值与肌肉减少症的关联 |
| 投稿时间：2024-10-17 修订日期：2024-11-11 点此下载全文 |
| 引用本文：崔峰,米晨,佘元华,杨含腾.单核细胞与高密度脂蛋白胆固醇比值与肌肉减少症的关联[J].医学研究杂志,2025,54(2):147-151, 158 |
| DOI：
10.11969/j.issn.1673-548X.2025.02.023 |
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| 基金项目:甘肃省自然科学基金资助项目(24JRRA331) |
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| 中文摘要:目的 探讨成年人群中单核细胞与高密度脂蛋白胆固醇比值(monocyte-to-high-density lipoprotein cholesterol ratio, MHR)与肌肉减少症之间的关联。方法 从2011~2018年4个周期的国家健康与营养调查(National Health and Nutrition Examination Survey, NHANES)中选取了8085例20岁及以上的参与者进行横断面研究。采用多元Logistic回归模型来评估MHR与肌肉减少症之间的关联。方差膨胀因子(variance inflation factors, VIF)检查变量间的多重共线性。通过限制性立方样条探究非线性关系,同时进行了交互作用检验和亚组分析。结果 在完全调整的模型中发现,MHR与肌肉减少症呈正相关(OR=2.56,95% CI:1.73~3.79,P<0.001)。这种关联在吸烟和心血管疾病参与者中更加突出。此外,限制性立方样条分析显示,MHR与肌肉减少症之间的关系是线性的。结论 MHR与肌肉减少症发病风险呈正相关,可能是早期识别肌肉减少症的潜在指标。 |
| 中文关键词:肌肉减少症 单核细胞与高密度脂蛋白胆固醇比值 横断面研究 |
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| Association between Monocyte-to-high-density lipoprotein cholesterol Ratio and Sarcopenia. |
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| Abstract:Objective To investigate the association between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and sarcopenia in an adult population. Methods A cross-sectional study was conducted with 8085 participants aged 20 years and older, selected from four cycles (2011-2018) of the National Health and Nutrition Examination Survey (NHANES). Multivariate Logistic regression model was used to evaluate the association between MHR and sarcopenia. Variance inflation factors (VIF) were calculated to assess multicollinearity between variables. Restricted cubic splines were employed to explore nonlinear relationships, with interaction tests and subgroup analyses performed as well. Results In the fully adjusted model, MHR was positively associated with sarcopenia (OR=2.56,95% CI:1.73-3.79,P<0.001). This association was more pronounced in participants with smoking history and cardiovascular disease. Additionally, restricted cubic spline analysis indicated a linear relationship between MHR and sarcopenia. Conclusion MHR is positively associated with the risk of sarcopenia and may serve as a potential early indicator for identifying sarcopenia. |
| keywords:Sarcopenia Monocyte-to-high-density lipoprotein cholesterol ratio Cross-sectional study |
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