| TIR联合SII炎性指数在2型糖尿病患者颈动脉粥样硬化中的应用价值 |
| 投稿时间：2024-08-13 修订日期：2024-09-27 点此下载全文 |
| 引用本文：于雪霏,黄莹芝.TIR联合SII炎性指数在2型糖尿病患者颈动脉粥样硬化中的应用价值[J].医学研究杂志,2025,54(2):166-171 |
| DOI：
10.11969/j.issn.1673-548X.2025.02.026 |
| 摘要点击次数: 585 |
| 全文下载次数: 160 |
|
| 基金项目:安徽省宿州市卫生健康科研项目(SZWJ2023a072) |
|
| 中文摘要:目的 探讨葡萄糖目标范围内时间(time in range, TIR)联合系统免疫炎性指数(systemic immune-inflammation index, SII)在诊断2型糖尿病(type 2 diabetes mellitus, T2DM)患者发生颈动脉粥样硬化(carotid atherosclerosis, CAS)中的应用价值。方法 采用回顾性研究方法,选取2022年8月～2024年4月蚌埠医科大学附属皖北煤电集团总医院收治的247例T2DM患者为研究对象,根据颈动脉超声结果分为无CAS组(n=106)和CAS组(n=141)；回顾性收集所有患者的一般资料、生化与血常规指标、持续葡萄糖监测(continuous glucose monitoring, CGM)参数进行统计分析；比较两组间各指标差异,多因素Logistic回归分析筛选T2DM患者发生CAS的独立危险因素,并绘制受试者工作特征(receiver operating characteristic, ROC)曲线评估TIR、SII及两者联合诊断T2DM患者发生CAS的价值。结果 与无CAS组患者比较,CAS组TIR水平显著降低,SII水平显著升高,差异有统计学意义(P<0.001)；多因素Logistic回归分析结果显示,年龄、收缩压、TIR、SII是T2DM患者发生CAS的独立危险因素(OR分别为1.120、1.029、-0.962、1.003,P<0.01)。ROC曲线分析结果显示,TIR的曲线下面积(area under the curve,AUC)为0.697,最佳截断值为82.6%；SII的AUC为0.672,最佳截断值为384.147；两者联合检测的AUC为0.740,优于单一检测(P<0.01)。结论 TIR、SII与T2DM患者颈动脉内中膜厚度增厚显著相关,TIR降低、SII升高是T2DM患者并发CAS的独立危险因素,两者联合诊断可提高对T2DM患者发生CAS的预测价值。 |
| 中文关键词:2型糖尿病 颈动脉粥样硬化 葡萄糖目标范围内时间 系统免疫炎性指数 |
| |
| Application Value of TIR Combined with SII in Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus. |
|
|
| Abstract:Objective To investigate the application value of glucose time in range (TIR) combined with systemic immune-inflammation index (SII) in diagnosing the occurrence of carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM). Methods Using a retrospective study method, a total of 247 patients with T2DM were admitted to the Wan Bei General Hospital of Wanbei Coal Power Group of Bengbu Medical University from August 2022 to April 2024, which were selected and divided into non-CAS group (n=106) and CAS group (n=141) according to the results of carotid ultrasound; the general data of all patients, biochemical and blood routine indexes, and continuous glucose monitoring (CGM) parameters were retrospectively collected and statistically analyzed; the differences in the indexes between the two groups were compared, and multivariate Logistic regression analysis was used to screen the independent risk factors for CAS in T2DM patients, and the value of TIR, SII and their combination in diagnosing CAS in T2DM patients were evaluated by drawing the receiver operating characteristic (ROC) curve. Results Compared with the patients in the non-CAS group, the TIR level was significantly lower and the SII level was significantly higher in the CAS group, and the differences were statistically significant (P<0.001); The multivariate Logistic regression analysis results showed that age, systolic blood pressure, TIR and SII were the independent risk factors for the occurrence of CAS in T2DM patients (OR were 1.120,1.029, -0.962,1.003, P<0.01). ROC curve analysis showed that the area under the curve (AUC) of TIR was 0.697, with an optimal cut-off value of 82.6%; The AUC of SII was 0.672, with an optimal cut-off value of 384.147; The AUC of the combined detection was 0.740, which was superior to that of single detection (P<0.01). Conclusion TIR and SII were significantly correlated with the thickening of the carotid artery intima-media thickness in patients with T2DM, the decreased TIR and elevated SII are independent risk factors for the complication of CAS in patients with T2DM, and the combined diagnosis of the two can improve the predictive value of the occurrence of CAS in patients with T2DM. |
| keywords:Type 2 diabetes mellitus Carotid atherosclerosis Time in range Systemic immune-inflammation index |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
