| 新疆地区孕妇血清学产前筛查结果特征分析 |
| 投稿时间：2024-08-12 修订日期：2024-11-07 点此下载全文 |
| 引用本文：蒋坚,申梦妮,代文成,李慧君.新疆地区孕妇血清学产前筛查结果特征分析[J].医学研究杂志,2025,54(3):90-94, 207 |
| DOI：
10.11969/j.issn.1673-548X.2025.03.017 |
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| 基金项目:新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(WJWY-202314)；乌鲁木齐市妇幼保健院科技计划项目(202201) |
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| 中文摘要:目的 分析新疆地区孕妇血清学产前筛查结果的特征,为新疆地区出生缺陷防治工作提供参考依据。方法 回顾性分析2022年1月~2023年12月于乌鲁木齐市妇幼保健院产前诊断中心接受中孕期血清学产前筛查的50781例单胎妊娠孕妇的临床资料。比较不同体重组、预产年龄组所对应的孕妇血清中甲胎蛋白(alpha-fetoprotein,AFP)、游离人绒毛膜促性腺激素β亚基(free beta-chorionic gonadotropin,Freeβ-HCG)、游离雌三醇(free ultra estriol,uE3)的水平,以及12个地级市、地区和自治州(以下简称地州)和7个孕妇群体最大的民族之间的AFP、Freeβ-HCG、uE3水平的差异。结果 新疆地区血清学产前筛查的高风险率为6.00%,产前诊断率为27.56%,阳性预测值为1.84%。产前筛查AFP、Freeβ-HCG、uE3水平与孕妇体重及预产年龄呈反比。新疆各地州及各民族孕妇血清中AFP、Freeβ-HCG、uE3水平存在差异(P＜0.05)。结论 本研究初步确定了新疆地区12个地州及7个常住民族血清学产前筛查AFP、Freeβ-HCG、uE3的中位数,产前筛查中心针对地州及民族进行中位数体系的修正,对提高新疆地区优生优育的服务能力具有重要意义。 |
| 中文关键词:新疆维吾尔自治区 产前筛查 中位数 民族 出生缺陷 |
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| Analysis of the Characteristics of Prenatal Screening Results for Pregnant Women in Xinjiang. |
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| Abstract:Objective To analyze the characteristics of serological prenatal screening results of pregnant women in Xinjiang, and provide reference basis for the prevention and control of birth defects in Xinjiang. Methods The clinical data of 50781 pregnant women with singleton pregnancies who underwent mid-trimester serological prenatal screening at the Prenatal Diagnosis Center, Urumqi Maternal and Child Health Care Hospital from January 2022 to December 2023 were retrospectively analyzed. The levels of alpha-fetoprotein (AFP), free beta-chorionic gonadotropin (Freeβ-HCG) and free ultra Estriol (uE3) in the serum of pregnant women corresponding to different weight groups and pre-delivery age groups, and the differences in AFP, Freeβ-HCG and uE3 levels among 12 prefectures and 7 ethnic groups with the largest group of pregnant women were compared. Results The high-risk rate of serological prenatal screening in Xinjiang was 6.00%, the prenatal diagnosis rate was 27.56%, and the positive predictive value was 1.84%. The levels of AFP, Freeβ-HCG and uE3 were inversely correlated with maternal weight and expected age before delivery. There were differences in the levels of AFP, Freeβ-HCG, uE3 in the serum of pregnant women from various prefectures and ethnic groups in Xinjiang (P<0.05). ConclusionThis study preliminarily determined the median of serological prenatal screening for AFP, Freeβ-HCG and uE3 in 12 prefectures and 7 permanent ethnic groups in Xinjiang. The prenatal screening center has revised the median system for prefectures and ethnic groups, which is of great significance for improving the service capacity of eugenics and childcare in Xinjiang. |
| keywords:Xinjiang Uygur Autonomous Region Prenatal screening Median Nation Birth defect |
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