| 基于隐结构模型探析儿童非霍奇金淋巴瘤癌因性疲乏中医证候分布及特征 |
| 投稿时间：2024-11-19 修订日期：2024-11-25 点此下载全文 |
| 引用本文：董子琪,路璐,黄静,段彦,龙金 玲,陈昱汝,甘国凌,高蓁.基于隐结构模型探析儿童非霍奇金淋巴瘤癌因性疲乏中医证候分布及特征[J].医学研究杂志,2025,54(4):130-135, 145 |
| DOI：
10.11969/j.issn.1673-548X.2025.04.023 |
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| 基金项目:北京市医院管理中心儿科学科协同发展中心儿科专项(XTGL201914)；北京市医院管理局儿科学科协同发展中心儿科专项重点项目(XTZD20180204) |
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| 中文摘要:目的 探讨儿童非霍奇金淋巴瘤癌因性疲乏(cancer-related fatigue,CRF)中医证候分布规律,为临床治疗提供依据。方法 单中心采集2023年7月～2024年7月103例确诊儿童非霍奇金淋巴瘤CRF患儿的中医四诊信息,建立数据库。采用Lantern 5.0软件,通过隐结构模型分析儿童非霍奇金淋巴瘤CRF的中医常见证候、症状特征。结果 高频症状、体征75个,包括尿黄、全身乏力、精神疲倦、苔厚腻、心烦易怒等。构建隐结构模型得到5个证候,依此制定辨识规则对CRF患儿进行二次辨证,其证候类型从高到低依次为心脾积热、湿热蕴结证、气虚瘀阻证、肝气郁结证、心肝血虚证。结论 儿童非霍奇金淋巴瘤CRF的证候类型以虚实夹杂证为主,在气虚、血虚、阴虚的基础上,兼见热、瘀、湿、积等病理因素。研究最终得到儿童非霍奇金淋巴瘤CRF的5类证型,受小儿病生理特点的影响,证型分布有别于成人。治疗时宜在扶助正气的基础上,同时注重消食化积、调气泻热之法,尤其要顾护小儿肺脾肾三脏。 |
| 中文关键词:儿童 非霍奇金淋巴瘤 癌因性疲乏 隐结构模型 证候 |
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| Exploring the Distribution and Characteristics of Cancer-related Fatigue Evidence in Children with Non-Hodgkin′s Lymphoma Based on a Hidden Structural Model. |
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| Abstract:Objective To explore the distribution pattern of Chinese medicine symptoms in childhood non-Hodgkin′s lymphoma cancer-related fatigue(CRF)and provide a basis for clinical treatment.Methods Information on the four TCM diagnoses of 103 children diagnosed with childhood non-Hodgkin′s lymphoma CRF from July 2023 to July 2024 was collected from a single centre,and a database was established.Lantern 5.0software was used to analyse the characteristics of common TCM signs and symptoms of children with non-Hodgkin′s lymphoma CRF by hidden structure model. Results Seventy-five high-frequency symptoms and signs,including yellow urine,general weakness,mental fatigue,thick and greasy moss,and irritability.Hidden structure model was constructed to obtain 5syndromes,according to which the identification rules were formulated for the secondary identification of children with CRF,and their syndromes types were,in descending order,heart-spleen stagnant heat,dampness-heat accumulation syndromes,qi deficiency and stasis,liver-qi stagnation syndromes,and heart-liver-blood deficiency syndromes.Conclusion The symptom types of CRF in children with non-Hodgkin′s lymphoma were mainly deficiency and mixed reality syndromes,with pathological factors such as heat,stasis,dampness and accumulation on the basis of deficiency of qi,blood and yin.The study finally obtained five types of CRF in children with non-Hodgkin′s lymphoma,and the distribution of the types is different from that of adults due to the influence of paediatric characteristics and pathophysiological characteristics.The treatment should be based on supporting the positive qi,and at the same time focusing on the method of eliminating food and resolving accumulation,regulating qi and diarrhoea,especially taking care of the lung,the spleen and the kidney of children. |
| keywords:Children Lymphoma Cancer-related fatigue Crypto-structural model Evidence |
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