| 探讨45～60岁人群TG/HDL-C与脑梗死的相关性 |
| 投稿时间：2024-11-07 修订日期：2024-12-03 点此下载全文 |
| 引用本文：王也,张诗雯,邹鑫,刘婷,李晶.探讨45～60岁人群TG/HDL-C与脑梗死的相关性[J].医学研究杂志,2025,54(5):23-28 |
| DOI：
10.11969/j.issn.1673-548X.2025.05.006 |
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| 基金项目:国家自然科学基金资助项目(81674056)；天津市科委自然科学基金资助项目(18JCYBJC 94200) |
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| 中文摘要:目的 探讨45～60岁人群甘油三酯(triglyceride,TG)与高密度脂蛋白胆固醇(high- density lipoprotein cholesterol, HDL-C)比值与脑梗死(cerebral infarct, CI)的相关性,并分析这种相关性在性别之间的差异。方法 该研究将患者分为CI不合并2型糖尿病(type 2diabetes, T2DM)组(CI-NG组, HbA1c<5.9%)和CI伴T2DM组(CI-T2DM组,HbA1c≥6.5%),将TG/HDL-C分成三分位数(T1<1.08,1.08≤T2<1.72,T3≥1.72),以T1为参照,采用二元Logistic回归分析TG/HDL-C与CI的关系,并根据性别进行分层讨论。结果 在1495例受试者中,CI-T2DM组的患者有423(28.29%)例。二元Logistic回归结果显示TG/HDL-C与CI-T2DM患者具有显著相关性(P<0.001),这种相关性是CI-NG患者的1.207倍(OR=1.207)。校正混杂因素后发现,这种相关性增强(OR=1.317),TG/HDL-C的最高三分位数与CI-T2DM患者的相关性是最低三分位数的3.277倍(OR=3.277)。根据性别的分层显示,TG/HDL-C与不同性别的CI-T2DM患者均具有显著相关性(P<0.001),但女性患者更显著(OR=2.000)高于男性患者(OR=1.224)。女性TG/HDL-C的最高三分位数与CI-T2DM患者的相关性是最低三分位数的5.598倍(OR=5.598)。结论 在45～60岁的人群中,与CI-NG患者比较,TG/HDL-C与CI-T2DM患者之间的相关性更加显著,并呈正相关,且在女性患者中更加明显。 |
| 中文关键词:脑梗死 二型糖尿病 TG/HDL-C 胰岛素抵抗 中年女性 |
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| Exploring the Correlation between TG/HDL-C and Cerebral Infarction in 45-60 Year Olds |
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| Abstract:Objective To investigate the correlation between triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) ratios and cerebral infarct (CI) in people aged 45-60 years, and to analyze the difference of this correlation between genders. Methods In this study, patients were divided into CI without type 2diabetes (T2DM) group (CI-NG group, HbA1c<5.9%) and CI with T2DM group (CI-T2DM group, HbA1c≥6.5%), and TG/HDL-C was divided into tertiles (T1<1.08,1.08≤T2<1.72, T3≥1.72), and the relationship between TG/HDL-C and CI was analyzed by binary Logistic regression using T1 as a reference, and stratified according to sex for discussion. Results Among 1495subjects, 423 (28.29%) patients were in the CI-T2DM group.Binary Logistic regression showed a significant correlation between TG/HDL-C and CI-T2DM patients (P<0.001), and this correlation was 1.207 times higher than that of CI-NG patients (OR=1.207). Correction for confounders revealed that this correlation was enhanced (OR=1.317), with the highest tertile of TG/HDL-C correlating 3.277 times more than that of CI-T2DM patients (OR=3.277). Stratification according to gender showed that TG/HDL-C was significantly correlated with CI-T2DM patients of different genders (P<0.001), but more significantly in female patients (OR=2.000) than in male patients (OR=1.224). The highest tertile of TG/HDL-C in women was 5.598 times more correlated with CI-T2DM patients than the lowest tertile (OR=5.598). Conclusion In people aged 45 to 60 years, the correlation between TG/HDL-C and CI-T2DM patients was more significant compared with CI-NG patients and was positively correlated and was more pronounced in female patients. |
| keywords:Cerebral infarction T2DM TG/HDL-C Insulin resistance Middle-aged women |
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