| 基于近10年国家自然科学基金资助项目探讨痛风及高尿酸血症研究现状 |
| 投稿时间：2024-12-13 修订日期：2024-12-31 点此下载全文 |
| 引用本文：刘明煊,方锦颖,谢存香,赵璐明,王浩,王海隆.基于近10年国家自然科学基金资助项目探讨痛风及高尿酸血症研究现状[J].医学研究杂志,2025,54(5):60-66 |
| DOI：
10.11969/j.issn.1673-548X.2025.05.012 |
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| 基金项目:国家重点研发计划项目(2022YFC3501203)；国家自然科学基金资助项目(82374278)；北京中医药大学东直门医院临床研究和成果转化能力提升试点项目(DZMG-XZYY-23006) |
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| 中文摘要:目的 对2014~2023年国家自然科学基金(Natural Science Foundation of China,NSFC)资助痛风和高尿酸血症项目进行分析,探讨近10年痛风和高尿酸血症基础研究的热点和现状,为未来该领域的研究提供参考。方法 使用NSFC大数据知识管理服务门户等数据库检索数据,检索关键词为“痛风”、“高尿酸血症”,建立项目数据库,对纳入的关键词进行清洗并进行关键词可视化分析。结果 近10年共立项203项,总资助金额8458.80万元。资助项目共有5种,涉及4个学部,包含27个一级学科,立项数最多的一级学科为中药学。上海市立项数最多,青岛大学立项数及资助金额最多。研究者共178人,获得2次及以上资助的有21人,其中立项数最多的是青岛大学李长贵。研究热点为“炎症”为主的病生理环节、信号通路和关键靶点、致病基因和新基因发现、多系统损害、中医药研究、新技术和新方法。结论 希望未来NSFC能增加对痛风和高尿酸血症项目的资助力度,研究者们使用更多前沿技术和创新方法,开展多学科交叉研究,融合中西医之精华,进一步阐释疾病机理,为痛风和高尿酸血症的临床诊疗提供新思路。 |
| 中文关键词:国家自然科学基金 痛风 高尿酸血症 研究热点 可视化 |
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| Exploration the Current Research Status of Gout and Hyperuricemia:A Review of Projects Funded by National Natural Science Foundation of China in the Past Decade. |
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| Abstract:Objective To Analyze the projects funded by the National Natural Science Foundation of China (NSFC) in the field of gout and hyperuricemia from 2014 to 2023, explore the hotspots and current status of basic research in the past decade in order to provide references for future research in this field. Methods Data were retrieved from databases such as The NSFC official website and so on, with the search Keywords being "gout" and "hyperuricemia", covering the time span from 2014 to 2023. Establish a project database and clean the included Keywords for statistical analysis and visualization. Results In the past decade, a total of 203 projects have been approved, with a total funding amount of 84.588million yuan. The funded projects include 5 types, involve 4 faculties, include 27 first-level disciplines, and the first-level discipline with the largest number of projects is Traditional Chinese Pharmacy. Shanghai has the largest number of projects, and Qingdao University has the largest number of projects and funding amounts. There are a total of 178 researchers, and 21 of them have received two or more grants, among which Li Changgui from Qingdao University has the largest number of approved projects. The researches focus on the pathophysiological links primarily centered on "inflammation", signal pathways and key targets, pathogenic genes and the discovery of new genes, multi-system damage, studies on traditional Chinese medicine, new technologies and new methods. Conclusion It is hoped that in the future, the NSFC can increase the funding support for projects in the field of gout and hyperuricemia. Researchers should employ more cutting-edge technologies and innovative methods, carry out interdisciplinary research, integrate the essence of Chinese and Western medicine, further explain the disease mechanism, and provide new ideas for the clinical diagnosis and treatment of gout and hyperuricemia. |
| keywords:National Natural Science Foundation of China Gout Hyperuricemia Research hotspots Visualization |
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