| 血清白脂素、血管生成素样蛋白3与2型糖尿病并发周围血管病变的相关性研究 |
| 投稿时间：2024-10-30 修订日期：2024-12-17 点此下载全文 |
| 引用本文：尹孟奇,王春,余吟晨.血清白脂素、血管生成素样蛋白3与2型糖尿病并发周围血管病变的相关性研究[J].医学研究杂志,2025,54(5):73-77 |
| DOI：
10.11969/j.issn.1673-548X.2025.05.014 |
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| 基金项目:安徽省教育厅自然科学重点研究项目(2022AH051456) |
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| 中文摘要:目的 探讨血清白脂素(asprosin,Asp)、血管生成素样蛋白3(angiopoietin-like protein 3,ANGPTL3)水平与2型糖尿病并发周围血管病变(diabetic peripheral vascular disease,DPVD)的相关性,评估两者对DPVD的预测价值。方法 共纳入符合入组标准的2型糖尿病患者141例,将其分为非DPVD组(n=71)和DPVD组(n=70),另选取同期健康体检者为正常对照(NC)组(n=37),比较3组一般资料及Asp、ANGPTL3的表达水平,采用Spearman相关性分析探讨Asp、ANGPTL3的水平与各临床指标的相关性,采用Logistic回归分析DPVD的影响因素,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清Asp、ANGPTL3水平对DPVD的预测价值。结果 与非DPVD组比较,DPVD组血清Asp、ANGPTL3水平较高(P均<0.05)。Spearman相关性分析显示,Asp水平与年龄、收缩压(systolic blood pressure,SBP)、空腹血糖(fasting blood glucose ,FBG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、ANGPTL3呈正相关(P均<0.05)；ANGPTL3水平与年龄、SBP、舒张压(diastolic blood pressure,DBP)、FBG、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、LDL-C、Asp呈正相关(P均<0.05)。年龄、病程、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、TC、LDL-C、空腹C肽(fasting C-peptide,FCP)、Asp、ANGPTL3是DPVD的影响因素(P均<0.05),病程、TG、Asp、ANGPTL3是DPVD的独立影响因素(P均<0.05)。ROC曲线结果显示,Asp、ANGPTL3水平单独预测DPVD的AUC分别为 0.679、0.706,对应的敏感度分别为88.7%、78.9%,特异性分别为47.1%、55.7%；Asp、ANGPTL3水平联合预测DPVD的AUC为0.777,敏感度为80.3%,特异性为64.3%。结论 Asp、ANGPTL3对DPVD有一定的预测价值,且两者联合预测价值更高。 |
| 中文关键词:糖尿病周围血管病变 白脂素 血管生成素样蛋白3 |
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| Study on the Correlation between Asprosin, Angiopoietin-like Protein 3 and Peripheral Vascular Disease in Type 2 Diabetes Mellitus |
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| Abstract:Objective To investigate the relationship between asprosin (Asp) and angiopoietin-like protein 3 (ANGPTL3) levels and Diabetic Peripheral Vascular diseases in type 2diabetes mellitus Disease,DPVD) to evaluate their predictive value for DPVD. Methods A total of 141 patients with type 2diabetes who met the inclusion criteria were included and divided into non-DPVD group (n=71) and DPVD group (n=70), and healthy subjects in the same period were selected as normal control group (n=37). General data and expression levels of Asp and ANGPTL3 in the three groups were compared. Spearman correlation analysis was used to explore the correlation between Asp and ANGPTL3 levels and clinical indicators, and Logistic regression was used to analyze the influencing factors of DPVD.The predictive value of serum Asp and ANGPTL3 levels to DPVD was analyzed by receiver operating characteristic curve (ROC). Results Compared with non-DPVD group, the levels of asprosin and angiopoietin-like protein 3 in DPVD group were higher (all P<0.05). Spearman correlation analysis showed that Asp level was positively correlated with age, SBP, FBG, LDL-C and ANGPTL3 (all P<0.05). ANGPTL3 level was positively correlated with age, SBP, DBP, FBG, TC, TG, LDL-C and Asp (all P<0.05). Age, course of disease, HbA1c, TG, LDL-C, FCP, Asp and ANGPTL3 were the influencing factors of DPVD (all P<0.05), while course of disease, TG, Asp and ANGPTL3 were the independent influencing factors of DPVD (all P<0.05). ROC curve results showed that Asp and ANGPTL3 levels alone predicted DPVD AUC of 0.679 and 0.706, corresponding sensitivity of 88.7% and 78.9%, specificity of 47.1% and 55.7%, respectively. The combined prediction of Asp and ANGPTL3 levels for DPVD was 0.777 AUC, 80.3% sensitivity and 64.3% specificity. Conclusion Asp and ANGPTL3have certain predictive value for DPVD, and their combined predictive value is higher. |
| keywords:Diabetic peripheral vascular disease Asprosin Angiopoietin-like protein 3 |
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