| 新疆维吾尔自治区4个区县居民全血金属浓度分析 |
| 投稿时间：2024-10-24 修订日期：2024-11-25 点此下载全文 |
| 引用本文：祝宇铭,王琛琛,达吾热尼·木合塔尔,林勤.新疆维吾尔自治区4个区县居民全血金属浓度分析[J].医学研究杂志,2025,54(5):83-87 |
| DOI：
10.11969/j.issn.1673-548X.2025.05.016 |
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| 基金项目:新疆维吾尔自治区自然科学基金资助项目(2021D01C123)；中国疾控中心达能基金资助项目(DIC2021-04) |
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| 中文摘要:目的 通过分析新疆维吾尔自治区4个区县全血金属暴露水平和分布特征,建立人群基线数据,为制定环境卫生及健康防控干预措施提供科学依据。方法 采用分层随机抽样方法,在新疆维吾尔自治区4个区县(阿勒泰市、乌鲁木齐市水磨沟区、乌恰县和泽普县)分别抽取3～80岁居民252人,采集1ml空腹静脉血,用电感耦合等离子体法(ICP-MS)检测全血金属浓度。SPSS 21.0统计学软件分析全血金属暴露水平的差异。结果 共筛检合格样本967份。将检出率达75%的金属元素铅、锰、镍纳入分析。结果显示,血铅中位数(四分位数间距)为15.91(11.47,22.41)μg/L；血锰中位数(四分位数间距)为10.11(8.29,12.56)μg/L；血镍中位数(四分位数间距)为0.90(0.63,1.17)μg/L。血铅、血锰、血镍浓度在不同地区间比较,差异有统计学意义(H分别为16.171、27.642、87.690,P<0.05)。血镍在城乡间比较,差异有统计学意义(H=19.261,P<0.05)。血铅、血锰在不同年龄间比较,差异有统计学意义(H分别为31.786、67.631,P<0.05)。血铅、血锰在性别间比较,差异有统计学意义(H分别为31.255、19.921,P<0.05)。结论 新疆维吾尔自治区4个区县居民有一定水平铅、锰、镍内暴露,且存在地区、城乡和人群差异,提示新疆维吾尔自治区居民可能处于环境多金属低水平联合暴露的潜在风险,需进一步开展相关研究。 |
| 中文关键词:血铅 血镉 血镍 生物监测 |
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| Analysis of Whole Blood Metal Concentrations in Residents of Four Counties in Xinjiang Uygur Autonomous Region |
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| Abstract:Objective By analyzing the levels and distribution characteristics of whole blood metal exposure in four districts and counties in Xinjiang, a population baseline data was established to provide scientific basis for the development of environmental hygiene and health prevention and control intervention measures.Methods Using a stratified random sampling method, 252 residents aged 3-80 were selected from four regions in Xinjiang (Altay City, Shuimogou District, Urumqi City, Wuqia County, and Zepu County). 1ml of fasting venous blood was collected and the whole blood metal concentration was detected by inductively coupled plasma mass spectrometry (ICP-MS). SPSS21.0statistical software was used to analyze the differences in whole blood metal exposure levels.Results A total of 967 qualified samples were screened. Include metal elements with a detection rate of 75% for lead, manganese, and nickel in whole blood for analysis. Blood lead M (Q1, Q3) is 15.91 (11.47,22.41) μg/L; blood manganese M (Q1, Q3) is 10.11 (8.29,12.56) μg/L;blood nickel M (Q1, Q3) is 0.90 (0.63,1.17)μg/L. There were statistically significant differences in the concentrations of blood lead, blood manganese, and blood nickel in different regions (H were 16.171,27.642,87.690, respectively, P<0.05).There is a statistically significant difference in blood nickel levels between urban and rural areas (H=19.261, P<0.05). There were statistically significant differences in blood lead and blood manganese levels among different ages (H were 31.786,67.631, P<0.05).There is a statistically significant gender difference in blood lead and blood manganese levels (H were 31.255,19.921, P<0.05).Conclusion Residents in four districts and counties in Xinjiang have certain levels of internal exposure to lead, manganese, and nickel, and there are regional, urban-rural, and population differences. It is suggested that residents in Xinjiang may be at a potential risk of low-level exposure to multiple metals in the environment, and further research is needed. |
| keywords:Blood lead Blood cadmium Blood nickel Biomonitoring |
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