| 参附注射液对脓毒性休克患者胃肠功能障碍疗效的临床研究 |
| 投稿时间：2024-11-19 修订日期：2024-12-18 点此下载全文 |
| 引用本文：袁子茜,王森,侯启亮,高兴梅,周洁容,窦志敏,李斌.参附注射液对脓毒性休克患者胃肠功能障碍疗效的临床研究[J].医学研究杂志,2025,54(5):124-128 |
| DOI：
10.11969/j.issn.1673-548X.2025.05.023 |
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| 基金项目:甘肃省卫生健康行业科研项目(GSWSKY2022-31) |
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| 中文摘要:目的 探讨参附注射液对脓毒性休克患者胃肠功能障碍临床疗效及预后的影响。方法 收集2021年9月~2024年4月兰州大学第一医院重症医学科诊断为脓毒性休克的患者,根据治疗方案分为参附组和常规治疗组,采用倾向性评分匹配法(propensity score matching,PSM)对两组患者进行1∶1匹配,记录两组患者纳入时的临床资料、治疗前及治疗5天后胃肠道的主要症状(呕吐、腹泻、腹胀、异常肠鸣音、胃潴留)、血乳酸(lactic acid, Lac)、白细胞介素(interleukin, IL)-6、降钙素原(procalcitonin,PCT)、白细胞(white blood cell, WBC)、中性粒细胞百分比(neutrophil percentage, NEUT%)、血乳酸/肌酐比值(lactic acid/ serum creatinine,Lac/SCr),以及出院后28天病死率。结果 治疗5天后,参附组患者胃肠道疗效改善的总有效率(66.23%)明显高于常规治疗组(35.06%,P<0.05)。与常规治疗组比较,参附组Lac、WBC、Lac/SCr水平下降(P<0.05),IL-6、PCT、NEUT%无明显差异(P>0.05)。与治疗前比较,治疗5天后参附组IL-6、Lac、Lac/SCr水平下降(P<0.05),PCT、WBC、NEUT%则差异无统计学意义(P>0.05)。两组患者出院后28天死亡率差异无统计学意义(P>0.05)。结论 参附注射液能改善脓毒性休克患者胃肠道功能障碍,减轻胃肠道症状,抑制炎性反应,改善胃肠组织灌注,并能在一定程度上改善脓毒性休克患者的短期预后。 |
| 中文关键词:脓毒性休克 参附注射液 胃肠功能障碍 预后 |
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| Clinical Study on the Therapeutic Effect of Shen-Fu Injection on Gastrointestinal Dysfunction in Patients with Septic Shock |
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| Abstract:Objective The study aimed to investigate the effect of Shen-Fu injection on the clinical efficacy and prognosis of gastrointestinal dysfunction in patients with septic shock. Methods Patients diagnosed with septic shock in the Department of Critical Care Medicine of the First Hospital of Lanzhou University from September 2021 to April 2024 were enrolled and divided into the Shen-Fu group and the conventional treatment group according to the treatment plan. The propensity score matching (PSM) was used for 1∶1 matching. Clinical data of patients in both groups at enrollment, the main gastrointestinal symptoms (vomiting, diarrhea, abdominal distension, abnormal bowel sounds, gastric retention), blood lactic acid(Lac), interleukin(IL)-6, procalcitonin(PCT), white blood cell(WBC), neutrophil percentage (NEUT%), the ratio of lactic acid to creatinine(Lac/SCr) before and 5days after treatment, and the mortality rate 28days after discharge were recorded. Results Compared with conventional treatment group (35.06%), the total effective rate (66.23%) of gastrointestinal efficacy in Shen-Fu group 5days after treatment was significantly higher (χ2=14.964, P < 0.05). The levels of Lac, WBC and Lac/SCr in Shen-Fu group was higher than that in conventional treatment group(P<0.05). There was no significant difference in IL-6, PCT and NEUT% (P>0.05). Compared with pre-treatment, the levels of IL-6, Lac, Lac/SCr decreased after 5days of treatment in Shen-Fu group (P<0.05), while there was no significant difference in PCT, WBC and NEUT% (P>0.05). There was no statistically significant difference in mortality rate between the two groups at 28days after discharge (P>0.05). Conclusion Shen-Fu Injection can improve gastrointestinal dysfunction in patients with septic shock, alleviate gastrointestinal symptoms, suppress inflammatory responses, enhance gastrointestinal tissue perfusion, and can improve the short-term prognosis of patients with septic shock to some extent. |
| keywords:Septic shock Shen-Fu injection Gastrointestinal dysfunction Prognosis |
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