| 甘油三酯-葡萄糖指数对代谢功能障碍相关脂肪肝患者死亡风险的预测价值 |
| 投稿时间：2024-08-19 修订日期：2025-01-01 点此下载全文 |
| 引用本文：于宗良,于滨洋,李敏,高蕊.甘油三酯-葡萄糖指数对代谢功能障碍相关脂肪肝患者死亡风险的预测价值[J].医学研究杂志,2025,54(6):34-38, 75 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.007 |
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| 基金项目:国家重点研发计划项目(2021YFF0901404)；中国中医科学院科技创新工程项目(CI2021A04701) |
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| 中文摘要:目的 探究甘油三酯-葡萄糖(triglyceride-glucose,TyG)指数对代谢功能障碍相关脂肪肝(metabolic dysfunction-associated steatotic liver disease,MASLD)患者死亡风险的预测价值。方法 基于美国国家健康与营养调查Ⅲ队列获取MASLD患者的资料。采用加权多变量COX比例风险回归模型来估计TyG指数与全因死亡和心血管死亡之间的关联。采用分段COX回归分析探索非线性关系及拐点两侧TyG指数与全因死亡和心血管死亡之间的关联。结果 TyG指数最低至最高四分位数全因死亡的危险比(hazard ratio,HR)分别为1.00、1.01、1.17和1.36,心血管死亡的HR分别为1.00、0.89、1.27和1.83。TyG指数与MASLD患者的全因死亡和心血管死亡呈U型关系。在拐点以上,TyG指数每增加1单位,全因死亡风险增加25%,心血管死亡风险增加46%。结论 TyG指数与MASLD患者的全因死亡和心血管死亡呈U型相关。监测TyG指数有助于评估MASLD患者的死亡风险。 |
| 中文关键词:甘油三酯-葡萄糖指数 代谢功能障碍相关脂肪肝 心血管死亡 全因死亡 |
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| Predictive Value of Triglyceride-Glucose Index on the Risk of Death in Patients with Metabolic Dysfunction-associated Steatotic Liver Disease. |
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| Abstract:Objective To investigate the predictive value of triglyceride-glucose (TyG) for the risk of death in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods Examination data of adult MASLD patients were obtained from the National Health and Nutrition Examination Survey. A weighted multivariate COX proportional risk model was used to estimate the association between TyG index and all-cause mortality and cardiovascular mortality. Segmented COX regression analysis was used to explore nonlinear relationships and associations between TyG index and all-cause mortality and cardiovascular mortality on either side of the inflection point. Results Hazard ratios for all-cause mortality in the lowest to the highest quartiles of the TyG index were 1.00,1.01,1.17 and 1.36, respectively. For cardiovascular mortality, hazard ratios were 1.00,0.89,1.27 and 1.83, respectively. There was a U-shape relationship between the TyG index and all-cause mortality and cardiovascular mortality in patients with MASLD. Above the inflection point, each one-unit increase in TyG index was associated with a 25% increase in the risk of all-cause mortality and a 46% increase in the risk of cardiovascular mortality. Conclusion TyG index is U-shapedly associated with all-cause mortality and cardiovascular mortality in patients with MASLD. Monitoring the TyG index is useful in assessing the risk of death in patients with MASLD. |
| keywords:Triglyceride-glucose index Metabolic dysfunction-associated steatotic liver disease Cardiovascular mortality All-cause mortality |
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