| 炎症性肠病患者病程与焦虑、抑郁、睡眠障碍和生活质量的相关性分析 |
| 投稿时间：2024-10-28 修订日期：2025-01-13 点此下载全文 |
| 引用本文：邱美琪,刘传,甄军海,刘忠纯,吴开春,董卫国.炎症性肠病患者病程与焦虑、抑郁、睡眠障碍和生活质量的相关性分析[J].医学研究杂志,2025,54(6):64-69, 163 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.012 |
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| 基金项目:国家自然科学基金资助项目(82170549) |
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| 中文摘要:目的 探讨炎症性肠病(inflammatory bowel disease, IBD)患者疾病病程与其焦虑、抑郁、睡眠质量和生活质量之间的相关性。方法 于2021年9月～2022年5月在全国22个省(自治区、直辖市)的42家医院进行横断面调查研究。收集自愿参与调研的确诊IBD的成人患者的一般临床资料和疾病病程,分别采用广泛性焦虑障碍量表(generalized anxiety disorder, GAD-7)、抑郁症筛查量表(patient health questionnaire-9, PHQ-9)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index, PSQI)和IBD生活质量量表(inflammatory bowel disease questionnaire, IBDQ)评估IBD 患者的焦虑、抑郁、睡眠质量和生活质量。结果共回收有效问卷2476份。其中458例(18.50%)患者病程在1年内,481例(19.43%)患者病程在1～2年,764例(30.86%)患者病程在2～5年,529例(21.37%)患者病程在5～10年,244例(9.85%)患者病程在10年以上。不同病程组GAD-7评分(P=0.005)、PHQ-9评分(P=0.002)、PSQI评分(P=0.005)比较,差异均有统计学意义。病程在5～10年的IBD患者更易出现抑郁、焦虑、睡眠障碍。不同病程组IBDQ评分比较,差异有统计学意义(P=0.005)。其中,肠道症状评分(P=0.001)、情感能力评分(P=0.013)、社会能力评分(P<0.001)比较,差异均有统计学意义。病程在2～5年的患者似乎拥有更好的生活质量,包括更轻的肠道症状、更好的情感和社会能力,病程在10年以上的患者拥有更好的社会能力。结论 焦虑、抑郁、睡眠障碍和生活质量与IBD患者的疾病病程相关,病程在5～10年的 IBD 患者更易出现抑郁、焦虑、睡眠障碍。 |
| 中文关键词:炎症性肠病 疾病病程 心理 睡眠质量 生活质量 |
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| Correlation Analysis between Disease Duration and Anxiety, Depression, Sleep Disorders and Quality of Life in Patients with Inflammatory Bowel Disease. |
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| Abstract:Objective To explore the correlation between disease duration and anxiety, depression, sleep quality and quality of life in patients with inflammatory bowel disease (IBD). Methods A cross-sectional survey study was conducted from September 2021 to May 2022 in 42hospitals in 22 provinces (autonomous regions and municipalities directly under the central government). General clinical information and disease duration of adult patients with IBD who voluntarily participated in the study were collected, and the anxiety, depression, sleep quality, and quality of life of IBD patients were assessed by using the Generalized Anxiety Disorder(GAD-7), the Patient Health Questionnaire-9 (PHQ-9), the Pittsburgh Sleep Quality Index(PSQI), and the Inflammatory Bowel Disease Questionnaire(IBDQ). Results A total of 2476 valid questionnaires were collected. Among them, 458 (18.50%) patients had a disease duration within 1 year, 481 (19.43%) patients had a disease duration of 1-2 years, 764 (30.86%) had a disease duration of 2-5 years, 529 (21.37%) had a disease duration of 5-10 years, and 244 (9.85%) had a disease duration of more than 10 years. The GAD-7score (P=0.005), PHQ-9score (P=0.002), and PSQI score (P=0.005) were statistically significant in different disease duration groups. In pairwise comparisons, IBD patients with a disease duration of 5-10 years were more likely to have depression, anxiety, and sleep disorder. IBDQ scores were statistically significant in different disease duration groups (P=0.005). Among them, bowel symptom score (P=0.001), emotional competence score (P=0.013), and social competence score (P<0.001) were statistically significant. Patients with a disease duration of 2-5 years seemed to have a better quality of life, including milder bowel symptoms, better emotional, and social competence. Patients with a disease duration of 10 years or more had better social competence. Conclusion Anxiety, depression, sleep disorders, and quality of life are associated with disease duration in patients with IBD, and patients with IBD with a disease duration of 5-10 years are more likely to have depressive states, anxiety and sleep states. |
| keywords:Inflammatory bowel disease Disease duration Psychology Sleep quality Quality of life |
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