| 估算脉搏波传导速度与2型糖尿病患者视网膜病变的关联 |
| 投稿时间：2024-11-08 修订日期：2024-12-30 点此下载全文 |
| 引用本文：肖瑶,徐明君,魏蜀吴,潘欣渝,魏军平.估算脉搏波传导速度与2型糖尿病患者视网膜病变的关联[J].医学研究杂志,2025,54(6):70-75 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.013 |
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| 基金项目:中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023084)；中国中医科学院科技创新工程项目(CI2021A01617)；中国中医科学院中医药循证能力建设项目(60104)；中央高水平中医院医院临床科研业务领军人才培育项目(CZ40905) |
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| 中文摘要:目的 探讨估算脉搏波传导速度(estimated pulse wave velocity, ePWV)与糖尿病视网膜病变(diabetic retinopathy, DR)的相关性。方法 回顾性选取2018年1月～2022年12月于笔者医院内分泌科住院的7468例2型糖尿病(type 2 diabetes mellitus, T2DM)患者,根据眼底检查情况将其分为DR组与无DR组。采用二元Logistic回归分析ePWV与DR患病率之间的关系。结果 DR组的ePWV明显高于无DR组(P<0.001)；与ePWV最低四分位组比较,其余3组DR患病率显著升高(Q1 23.2%, Q2 30.4%, Q3 31.9%, Q4 30.1%, P<0.001)；按DR分组的ePWV最佳截断值为9.27m/s,高ePWV组DR患病率显著高于低ePWV组(30.9% vs 22.4%, P<0.001)。ePWV是DR的危险因素(OR=1.070, P<0.001),但会受到年龄、性别、舒张压、血脂和肾功能的影响；而ePWV>9.27m/s是独立于糖尿病相关因素(OR=1.421,P<0.001)及一般情况及其他混杂因素(OR=1.494, P<0.001)之外的DR患病危险因素。结论 ePWV与DR相关,高ePWV的T2DM患者患DR的风险更高。 |
| 中文关键词:估算脉搏波传导速度 动脉僵硬度 糖尿病视网膜病变 危险因素 |
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| Correlation between Estimated Pulse Wave Velocity and Retinopathy in Patients with Type 2 Diabetes Mellitus. |
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| Abstract:Objective To explore the correlation between estimated pulse wave velocity (ePWV) and diabetic retinopathy (DR). Methods Totals of 7468 patients with type 2 diabetes mellitus (T2DM) who were hospitalized from January 2018 to December 2022 were retrospectively selected and classified into the DR group and the no DR group based on fundus examination. Logistic regression was used to analyze the relationship between ePWV, its quartile and cutoff value strata, and the prevalence of DR. Results The ePWV level in the DR group was significantly higher than that in no DR group (P<0.001); the prevalence of DR was significantly higher in the remaining three groups compared to the lowest quartile of ePWV (Q1 23.2%, Q2 30.4%, Q3 31.9%, Q4 30.1%, P<0.001); the ePWV cutoff value was 9.27m/s, and the high ePWV group DR prevalence was significantly higher than in the low ePWV group (30.9% vs 22.4%, P<0.001). ePWV was a risk factor for DR prevalence (OR=1.070, P<0.001) but was affected by age, sex, diastolic blood pressure, lipids, and renal function; whereas, ePWV>9.27m/s was a risk factor for the prevalence of DR independently of diabetes-related factors (OR=1.421, P<0.001) and general condition and other confounding factors (OR=1.494, P<0.001) in addition to risk factors for DR prevalence. Conclusion ePWV was associated with DR prevalence, and T2DM patients with high ePWV levels were at higher risk of having DR. |
| keywords:Estimated pulse wave velocity Arterial stiffness Diabetic retinopathy Risk factors |
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