| 不同疫苗接种状态儿童百日咳住院患儿的临床特征分析 |
| 投稿时间：2025-03-01 修订日期：2025-03-06 点此下载全文 |
| 引用本文：康利民,米荣,王亚娟,崔小岱,伏瑾,李莉,李铁耕.不同疫苗接种状态儿童百日咳住院患儿的临床特征分析[J].医学研究杂志,2025,54(6):82-86 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.015 |
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| 基金项目:北京市自然科学基金资助项目(7192028) |
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| 中文摘要:目的 探讨不同百日咳疫苗接种状态儿童百日咳住院患儿的临床特征。方法 回顾性收集2011年3月～2022年2月首都儿科研究所附属儿童医院儿童百日咳住院患儿的人口学资料和临床资料。根据百日咳疫苗接种状态分为未接种组、未完全接种组(接种1剂或2剂)和完全接种组(接种3剂),对3组临床资料进行比较。结果 共纳入270例儿童百日咳住院患儿。未接种组206例(76.3%),未完全接种组24例(8.9%),完全接种组40例(14.8%)。3组患儿发病年龄总体之间比较,差异有统计学意义(P<0.05),完全接种组发病年龄最高。3组发生低氧血症、心率下降、痉挛性咳嗽、阵发性青紫、咳嗽时面色潮红的比例,以及外周血淋巴细胞比例升高(≥0.6)的比例总体之间差异均有统计学意义(P<0.05),完全接种组的比例均低于未接种组。3组发生重症百日咳和需要机械通气治疗(有创或无创)的比例总体之间比较,差异均有统计学意义(P<0.05),完全接种组的比例均低于未接种组。结论 完全接种百日咳疫苗,对于减轻儿童百日咳临床症状、降低外周血淋巴细胞增多的程度和减少重症百日咳的发生有重要作用。 |
| 中文关键词:百日咳 百日咳疫苗 儿童 临床特征 |
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| Clinical Characteristics of Hospitalized Children with Pertussis Stratified by Vaccination Status. |
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| Abstract:Objective To investigate the clinical characteristics of hospitalized children with pertussis based on their pertussis vaccination status.Methods From March, 2011 to February, 2022, children with pertussis hospitalized at the Children′s Hospital Affiliated to Capital Institute of Pediatrics were retrospectively selected. Information was analyzed regarding demographic data and clinical data, Patients were divided into three groups based on vaccination status:non-vaccinated, incompletely vaccinated (1dose or 2doses), and completely vaccinated (3doses). Clinical features were compared among the groups.Results A total of 270 children hospitalized with pertussis were included. The non-vaccinated group comprised 206 cases (76.3%), the incompletely vaccinated group comprised 24 cases (8.9%), and the completely vaccinated group comprised 40 cases (14.8%). Statistically significant differences were observed in the overall age of onset among the three groups (P<0.05), with the completely vaccinated group having the highest age of onset. Significant differences were also noted in the proportions of hypoxemia, decreased heart rate, paroxysmal cough, episodic cyanosis, facial flushing during coughing, and elevated peripheral blood lymphocyte proportion (≥0.6) across the groups (P<0.05), with the completely vaccinated group showing lower rates compared to the non-vaccinated group. Additionally, significant differences were observed in the rates of severe pertussis and the need for mechanical ventilation (invasive or non-invasive) among the groups (P<0.05), with the completely vaccinated group having lower rates than the non-vaccinated group. Conclusion Complete vaccination, plays a critical role in alleviating clinical symptoms, reducing peripheral blood lymphocytosis, and decreasing the incidence of severe pertussis in children. |
| keywords:Pertussis Pertussis vaccine Children Clinical Characteristics |
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