| S100A7、IGF-1、RAGE在Ⅰ型子宫内膜癌组织中的表达及临床意义 |
| 投稿时间：2025-01-08 修订日期：2025-01-28 点此下载全文 |
| 引用本文：张佩,丁薇,陆晓媛,杜文升.S100A7、IGF-1、RAGE在Ⅰ型子宫内膜癌组织中的表达及临床意义[J].医学研究杂志,2025,54(6):87-91, 86 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.016 |
| 摘要点击次数: 13 |
| 全文下载次数: 7 |
|
| 基金项目:江苏省妇幼健康科研项目(F201903)；江苏省徐州市科技项目(KC22246) |
|
| 中文摘要:目的 探究S100钙结合蛋白A7(S100 cabinding protein A7,S100A7)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)在Ⅰ型子宫内膜癌(endometrial carcinoma, EC)组织中的表达及临床意义。方法 选取60例Ⅰ型EC患者组织和30例正常子宫内膜组织,运用实时荧光定量聚合酶链反应(real-time fluorescent quantitative polymerase chain reaction,RT-qPCR)方法,检测各组织中S100A7、IGF-1、RAGE mRNA的表达情况。采用免疫组化法检测107例Ⅰ型EC组织、24例非典型增生内膜组织和30例正常内膜组织中S100A7、IGF-1、RAGE的蛋白表达情况,分析三者的相关性以及与患者临床病理特征的关系,采用Kaplan-Meier法绘制生存曲线,COX回归分析影响患者生存预后的因素。结果 与正常内膜组织比较,S100A7、IGF-1、RAGE mRNA在EC组织中的表达升高(P＜0.05)。S100A7、IGF-1、RAGE蛋白阳性率随着内膜病变的进展而升高,且三者呈正相关(P＜0.05)。不同国际妇产科联盟(International Federation of Gynecology and Obstetrics, FIGO)分期、有无淋巴结转移、不同组织分化程度Ⅰ型EC组织S100A7、IGF-1、RAGE的阳性率不同 (P<0.05)。Kaplan-Meier生存分析结果显示,S100A7、IGF-1、RAGE阳性表达患者的平均生存时间短于阴性表达患者。COX回归分析结果显示,淋巴结转移、高表达S100A7、高表达IGF-1及高表达RAGE是Ⅰ型子宫内膜癌患者预后的独立危险因素。结论S100A7、IGF-1、RAGE在Ⅰ型EC组织中的表达水平增高,三者的阳性表达与子宫内膜癌的发生、发展和不良预后密切有关。 |
| 中文关键词:Ⅰ型子宫内膜癌 S100钙结合蛋白A7 胰岛素样生长因子-1 晚期糖基化终末产物受体 临床病理特征 预后 |
| |
| Expression and Clinical Significance of S100A7, IGF-1 and RAGE in Endometrial Carcinoma Type Ⅰ. |
|
|
| Abstract:Objective To investigate the expression and clinical significance of S100 cabinding protein A7 (S100A7), insulin-like growth factor-1 (IGF-1), and receptor for advanced glycation end products (RAGE) in type Ⅰ endometrial carcinoma (EC). Methods 60 patients with type Ⅰ EC and 30 normal endometrial tissues were selected and analyzed by real-time fluorescent quantitative polymerase chain reaction (RT-qPCR). RT-qPCR was used to detect the expression of S100A7, IGF-1 and RAGE mRNA in different endometrial tissues. The protein expression of S100A7, IGF-1 and RAGE in 107 type Ⅰ EC tissues, 24 cases endometrial tissues with atypical hyperplasia and 30 normal endometrial tissues were detected by immunohistochemical method. The correlation between the three and the clinicopathological characteristics of the patients was analyzed. Kaplan-Meier method was used to draw the survival curve, and COX regression analysis was performed to analyze the factors affecting the survival and prognosis of patients. Results The expressions of S100A7, IGF-1 and RAGE mRNA in EC tissues were increased compared with normal endometrial tissues (P<0.05). The positive rates of S100A7, IGF-1 and RAGE proteins increased with the progression of endometrial lesions, and there was a significant positive correlation among them (P<0.05). For different International Federation of Gynecology and Obstetrics (FIGO) staging, presence or absence of lymph node metastasis, and degree of tissue differentiation in type Ⅰ EC, The positive rates of S100A7, IGF-1 and RAGE were different (P<0.05). Kaplan-Meier survival analysis showed that the average survival time of patients with positive expression of S100A7, IGF-1 and RAGE was lower.COX regression analysis showed that lymph node metastasis, high expression of S100A7, IGF-1 and RAGE were independent risk factors for prognosis of patients with type Ⅰ EC. Conclusion The increased expression levels of S100A7, IGF-1 and RAGE in type Ⅰ EC are closely associated with the emergence, progress and bleak prognosis of EC. |
| keywords:Type Ⅰ endometrial carcinoma S100A7 IGF-1 RAGE Clinicopathological characteristics Prognosis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
