| 微生物学快速现场评价联合支气管镜在重症肺炎中的应用价值 |
| 投稿时间：2024-12-12 修订日期：2025-01-01 点此下载全文 |
| 引用本文：许丹,刘小丽,莫亚斯尔·热合木拉,伊贝拜汗·买卖提,黄玉蓉.微生物学快速现场评价联合支气管镜在重症肺炎中的应用价值[J].医学研究杂志,2025,54(6):133-137, 174 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.024 |
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| 基金项目:新疆生产建设兵团医院科研计划项目(2023001)；兵团科技计划项目(2023AB018-06) |
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| 中文摘要:目的 本研究旨在评价微生物学快速现场评价(microbiological rapid onsite evaluation,M-ROSE)联合支气管镜在重症肺炎中的应用价值。方法 共纳入符合标准的重症肺炎患者170例,根据是否行M-ROSE技术分为两组,每组85例。M-ROSE组经支气管镜肺泡灌洗获取标本,然后使用M-ROSE技术指导治疗,对照组经支气管镜肺泡灌洗后给予经验性治疗。比较两组临床疗效、抗生素使用情况、住院情况,比较M-ROSE和支气管镜肺泡灌洗液(bronchoalveolar lavage fluid,BALF)涂片、培养结果的一致性,比较M-ROSE和BALF涂片、培养时间。结果 M-ROSE组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。M-ROSE组抗生素使用时间及费用,住院时间均小于对照组,差异均有统计学意义(P＜0.05)。M-ROSE结果与BALF涂片结果一致性极好(Kappa=0.799,P＜0.001),M-ROSE结果与BALF培养结果一致性中、高度(Kappa=0.609,P＜0.001),M-ROSE报告的获得速度明显快于BALF涂片、培养(P＜0.001)。结论 M-ROSE联合支气管镜对重症肺炎患者病原体的初步评估有很高的价值,在一定程度上可以提高治疗有效率、减少抗生素使用时间及费用、减少住院时间。 |
| 中文关键词:重症肺炎 微生物学快速现场评价 支气管镜 |
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| Application Value of M-ROSE Combined with Bronchoscopy in Severe Pneumonia. |
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| Abstract:Objective To evaluate the value of microbiological rapid on-site evaluation (M-ROSE) combined with bronchoscopy in severe pneumonia. Methods A total of 170 patients with severe pneumonia who met the criteria were enrolled, and they were divided into two groups according to whether M-ROSE was performed or not,with 85 cases in each group. In the M-ROSE group,bronchoscopy was used for alveolar lavage to obtain samples,and then the M-ROSE technology was used to guide the treatment, and the control group was given empiric treatment after bronchoscopic alveolar lavage. The clinical efficacy, antibiotic use, and hospital stay were compared between the two groups. The consistency of M-ROSE and bronchoalveolar lavage fluid (BALF) smears and culture results were compared, and M-ROSE and BALF smears and culture time were compared. Results The total effective rate in the M-ROSE group was higher than that in the control group (P<0.05). The duration of antibiotic use, cost and hospital stay in the M-ROSE group were lower than those in the control group (P<0.05). The results of M-ROSE were in better agreement with the results of BALF smear (Kappa=0.799, P<0.001), and the results of M-ROSE were in good agreement with the results of BALF culture (Kappa=0.609, P<0.001). Conclusion M-ROSE combined with bronchoscopy is of high value for the initial assessment of pathogens in patients with severe pneumonia, and can improve the effective rate of treatment, reduce the time and cost of antibiotic use, and reduce the length of hospital stay to a certain extent. |
| keywords:Severe pneumonia Microbiological rapid onsite evaluation Bronchoscopy |
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