| 甘油三酯葡萄糖指数与结直肠息肉的相关性研究 |
| 投稿时间：2025-01-12 修订日期：2025-01-22 点此下载全文 |
| 引用本文：姚梦然,费爱华.甘油三酯葡萄糖指数与结直肠息肉的相关性研究[J].医学研究杂志,2025,54(6):155-158, 167 |
| DOI：
10.11969/j.issn.1673-548X.2025.06.028 |
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| 中文摘要:目的 研究甘油三酯葡萄糖(triglyceride-glucose, TyG)指数与结直肠息肉发病风险及其不同病理类型之间的相关性。方法 按照纳排标准选取2022年5月～2023年12月于上海交通大学医学院附属新华医院行纤维肠镜检查的患者453例,根据肠镜检查结果分为非结直肠息肉组和结直肠息肉组,根据病理结果将息肉组分为非腺瘤性息肉组、腺瘤性息肉组和结直肠癌组。回顾性分析研究对象的一般资料、血糖、血脂等相关检验指标,采用Logistic回归分析影响结直肠息肉发生的相关危险因素；构建受试者工作特征(receiver operating characteristic, ROC)曲线评估TyG指数对结直肠息肉发生的预测效能；比较不同病理类型结直肠息肉间的TyG水平是否存在差异性。结果 结直肠息肉组患者年龄、男性比例、体重指数(body mass index, BMI)、糖化血红蛋白(glycosylated hemoglobin, HbA1c)水平、甘油三酯(triglyceride, TG)水平、脂蛋白a水平、TyG指数高于非结直肠息肉组。校正影响因素后,Logistic回归分析结果显示TyG指数与结直肠息肉的发生具有相关性(P＜0.05)。TyG指数预测结直肠息肉发生的ROC曲线下面积(area under curve, AUC)为0.756(95% CI:0.702~0.809,P＜0.001)。非结直肠息肉组TyG指数低于非腺瘤性息肉组、腺瘤性息肉组、结直肠癌组,差异有统计学意义(P<0.05),4组两两比较差异均有统计学意义(P<0.05)。结论 TyG指数与结直肠息肉的发生可能具有相关性,不同病理类型结直肠息肉的TyG指数水平存在差异性。 |
| 中文关键词:结直肠息肉 TyG指数 病理类型 筛查 |
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| Correlation between Triglyceride-Glucose Index and Colorectal Polyps. |
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| Abstract:Objective To research the correlation between triglyceride-glucose index (TyG) and the risk of colorectal polyps with different pathological types. Methods According to inclusion and exclusion criteria, 453 patients who underwent fiberoptic colonoscopy at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from May 2022 to December 2023 were selected. Based on colonoscopy results, patients were divided into non-colorectal polyp group and a colorectal polyp group. The polyp group was further classified according to pathological results into non-adenomatous polyps, adenomatous polyps, and colorectal cancer groups. A retrospective analysis was conducted on the general data of the study subjects, including relevant test indicators such as blood glucose and lipids. Logistic regression analysis was employed to identify risk factors associated with the occurrence of colorectal polyps. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive role of the TyG index in the development of colorectal polyps, and the TyG levels among different pathological types of colorectal polyps were compared. Results Patients in the polyp group exhibited higher age, male proportion, body mass index (BMI), glycosylated hemoglobin (HbA1c), triglycerides (TG), lipoprotein(a), and TyG index compared to the non-polyp group. After adjusting for confounding factors, Logistic regression analysis indicated a correlation between the TyG index and the occurrence of colorectal polyps (P < 0.05). The area under the curve (AUC) for the TyG index predicting the development of colorectal polyps was 0.756 (95% CI:0.702-0.809, P < 0.001). The TyG index level in the non-colorectal polyp group was lower than that in the non-adenomatous polyp, adenomatous polyp, and colorectal cancer groups, with statistically significant differences (P < 0.05). Pairwise comparisons also showed statistically significant differences (P < 0.05). Conclusion The TyG index may be correlated with the occurrence of colorectal polyps. There are significant differences in the TyG index levels among different pathological types of colorectal polyps. |
| keywords:Colorectal polyps TyG index Pathological types Screening |
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