| 柴夏散结方治疗肺结节的临床疗效研究 |
| 投稿时间：2024-12-12 修订日期：2024-12-31 点此下载全文 |
| 引用本文：洪沁妍,张心怡,南富耀,杨洛琦,李磊,王洪武.柴夏散结方治疗肺结节的临床疗效研究[J].医学研究杂志,2025,54(7):123-128, 151 |
| DOI：
10.11969/j.issn.1673-548X.2025.07.022 |
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| 基金项目:中央高水平中医医院临床科研业务费资助项目(DZMG-GLZH-23002)；中国中药协会呼吸病药物研究专业委员会青年医师创新发展项目(HXQNJJ-2023-009) |
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| 中文摘要:目的 回顾性分析柴夏散结方治疗肺结节的临床疗效。方法 回顾性收集2021年1月～2024年6月北京中医药大学东直门医院呼吸科门诊接受柴夏散结方干预3个月及以上的肺结节肝郁气滞证患者107例作为观察组,并选取同期未接受中医药干预的107例肝郁气滞证肺结节患者作为对照组。收集患者的基本信息、中医证候,初诊、末诊时胸部HRCT所示肺结节直径。比较两组患者的结节直径变化、中医证候积分及中医证候疗效。结果 与对照组比较,观察组的肺结节直径较小,差异有统计学意义(P<0.05),且结节消失或缩小比例高于对照组,差异有统计学意义(P<0.05)。末诊时,观察组胸部满闷、情绪不宁、嗳气腹胀、胁肋胀痛、咽部异物感、口苦、不思饮食、大便不调、睡眠障碍等中医证候积分较初诊时及对照组均降低,差异有统计学意义(P<0.05)。观察组中医证候改善有效率为88.8%。结论 柴夏散结方可在一定程度上缩小肺结节直径,并改善患者的中医证候。 |
| 中文关键词:肺结节 中医药 柴夏散结方 证候积分 回顾性研究 |
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| Clinical Efficacy of Chaixia Sanjie Formula in Treating Pulmonary Nodules. |
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| Abstract:Objective To retrospectively analyze the clinical efficacy of the Chaixia Sanjie formula in treating pulmonary nodules. Methods Retrospective collection of 107 patients with pulmonary nodules and liver-qi stagnation syndrome who received the Chaixia Sanjie formula for 3months or more at Dongzhimen Hospital, Beijing University of Chinese Medicine, from January 2021 to June 2024 as the observation group. Another 107 patients with pulmonary nodules and liver-qi stagnation syndrome who did not receive traditional Chinese medicine(TCM) intervention during the same period were selected as the control group. Basic information, TCM syndromes, and the diameters of pulmonary nodules on chest HRCT at the first and last visit were collected. Changes in nodule diameter, TCM syndrome scores, and TCM therapeutic efficacy were compared between the two groups. Results Compared with the control group, the nodule diameter in the observation group was smaller and the difference was statistically significant(P<0.05), and the proportion of nodule disappearance or reduction was higher in the observation group than in the control group, and the difference was statistically significant(P<0.05). At the final diagnosis, the observation group showed a decrease in traditional Chinese medicine syndrome scores, including chest fullness, emotional instability, belching and bloating, rib pain, foreign body sensation in the throat, bitter mouth, lack of appetite, irregular bowel movements, and sleep disorders, compared to the initial diagnosis and the control group, with statistical significance(P<0.05). The effective rate of TCM syndrome improvement in the observation group was 88.8%. Conclusion The Chaixia Sanjie formula can reduce the diameter of pulmonary nodules to some extent and improve TCM syndromes in patients with pulmonary nodules. |
| keywords:Pulmonary nodules Traditional Chinese medicine Chaixia Sanjie formula Syndrome scores Retrospective study |
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