| TyG指数与非糖尿病脓毒症ICU病死率的关系 |
| 投稿时间：2025-02-03 修订日期：2025-03-15 点此下载全文 |
| 引用本文：蒋玉婧,王嘉琪,马莉.TyG指数与非糖尿病脓毒症ICU病死率的关系[J].医学研究杂志,2025,54(8):101-107 |
| DOI：
10.11969/j.issn.1673-548X.2025.08.017 |
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| 基金项目:甘肃省自然科学基金资助项目(22JR5RA965) |
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| 中文摘要:目的 评估甘油三酯葡萄糖(triglyceride-glucose, TyG)指数与非糖尿病脓毒症患者重症监护病房(intensive care unit,ICU)病死率之间的关系。方法 回顾性分析2018年1月～2023年12月兰州大学第二医院收治的脓毒症患者的病例资料。根据TyG指数的三分位数将患者分为3组,即T1组、T2组和T3组,主要结局指标是ICU病死率。采用多因素COX回归分析和限制性立方样条回归(restricted cubic spline,RCS)模型评估TyG指数与脓毒症患者ICU病死率是否存在潜在的非线性关系,并进行亚组分析进一步探讨该关系。结果 该研究共纳入578例脓毒症患者,ICU病死率为16.96％。Kaplan-Meier生存曲线分析结果显示,T3组的ICU病死率明显高于T1组。RCS分析结果显示,TyG指数与ICU病死率呈线性正相关,当TyG指数每增加1个单位,ICU病死率的风险增加约54%。亚组分析结果显示,不同亚组的效应方向一致,没有亚组特异性,表明结果具有稳定性。结论 TyG指数是预测非糖尿病脓毒症患者ICU病死率的潜在生物学标志物之一。 |
| 中文关键词:胰岛素抵抗 脓毒症 ICU病死率 甘油三酯葡萄糖指数 |
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| Relationship Between TyG Index and ICU Mortality of Non-diabetic Sepsis. |
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| Abstract:Objective To evaluate the relationship between triglyceride-glucose index (TyG) and intensive care unit (ICU) mortality in patients with non-diabetic sepsis. Methods The retrospective cohort study analyzed the data from sepsis patients admitted to the Second Hospital & Clinical Medical School, Lanzhou University between January 2018 and December 2023. The patients were divided into three groups based on the terartiles of the TyG index:group T1, group T2 and group T3, with ICU mortality as the primary endpoint. Multivariate COX regression analysis and restricted cubic spline (RCS) modeling were performed to investigate the potential non-linear relationship between the TyG index and ICU mortality of patients with sepsis, and subgroup analysis were conducted to further explore these relationships. Results This study included 578sepsis patients, with an ICU mortality of 16.96%. The Kaplan-Meier survival curve analysis indicated that the ICU mortality in the group T3 was significantly higher than that in the group T1. The RCS analysis revealed a linear relationship between the TyG index and ICU mortality, for every 1-unit increase in the TyG index, the risk of ICU mortality increased by approximately 54%. Subgroup analysis demonstrated consistent effect directions across different subgroups, with no subgroup-specific effects, indicating the robustness of the results. Conclusion TyG index may serve as a potential biomarker for predicting ICU mortality in non-diabetic sepsis patients. |
| keywords:Insulin resistance Sepsis ICU mortality Triglyceride-glucose index |
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