| 动脉弹性与左心室结构及功能的相关性分析 |
| 投稿时间：2025-07-24 修订日期：2025-08-02 点此下载全文 |
| 引用本文：刘智冉,陈彬,徐欣茹,吴寿岭,李雯,应涛.动脉弹性与左心室结构及功能的相关性分析[J].医学研究杂志,2025,54(9):79-85 |
| DOI：
10.11969/j.issn.1673-548X.2025.09.014 |
| 摘要点击次数: 29 |
| 全文下载次数: 15 |
|
| 基金项目:国家自然科学基金资助项目(面上项目)(82272018)；先进医疗装备应用示范项目(2018MND102012) |
|
| 中文摘要:目的 目的 探讨臂踝脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)与左心室结构和功能之间的相关性。方法 纳入2010年1月～2021年12月共4864例完成baPWV和经胸超声心动图检查的受试者。根据baPWV情况将其分为3组:T1组:baPWV<14m/s；T2组:14m/s≤baPWV<18m/s；T3组:baPWV≥18m/s。采用多因素Logistic回归和线性回归模型讨论baPWV与室间隔厚度(interventricular septal thickness,IVS)、左心室后壁厚度(left ventricular posterior wall thickness,LVPW)、左心室舒张末期内径(left ventricular end diastolic diameter,LVEDd)、左心室质量指数(left ventricular mass index,LVMI)、左心室射血分数(left ventricular ejection fraction,LVEF)和二尖瓣环e′/a′<1的相关性。结果 BaPWV升高与IVS增厚(β=0.095,95% CI:0.007~0.182)、LVPW增厚(β=0.145,95% CI:0.056~0.233)及二尖瓣环e′/a′<1(OR=2.200,95% CI:1.608~3.010)显著相关(P<0.05),与LVEDd呈负相关(β=-0.048,95% CI:-0.075~-0.021),与LVMI及LVEF则无相关性(P>0.05)。分层分析提示,收缩压与baPWV对LVEDd和二尖瓣环e′/a′<1存在交互作用(P<0.05)。结论 BaPWV与左心室重构及舒张功能具有相关性,baPWV与LVPW和LVEDd的相关性在收缩压未明显升高群体中更高,而与二尖瓣环e′/a′<1的相关性则在收缩压升高群体中更为显著。 |
| 中文关键词:臂踝脉搏波传导速度 经胸超声心动图 左心室结构 左心室功能 |
| |
| Association of Arterial Elasticity with Left Ventricular Structure and Function |
|
|
| Abstract:Objective To investigate the association between brachial-ankle pulse wave velocity (baPWV) and left ventricular structure and function. Methods A total of 4864 participants who completed baPWV and transthoracic echocardiography from January 2010 to December 2021were included. The participants were divided into three groups based on baPWV:Group T1:baPWV <14m/s; Group T2:14m/s ≤ baPWV <18m/s; Group T3:baPWV ≥18m/s. Multivariable Logistic regression and linear regression was used to examine the correlation between baPWV and interventricular septal thickness (IVS), left ventricular posterior wall thickness (LVPW), left ventricular end diastolic diameter (LVEDd), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), and the presence of mitral e′/a′<1. Results Increased baPWV was significantly associated with thickening of IVS (β=0.095,95% CI:0.007-0.182), thickening of LVPW (β=0.145,95% CI:0.056-0.233), and mitral e′/a′<1 (OR=2.200,95% CI:1.608-3.010) (P<0.05). It was negatively correlated with LVEDd (β=-0.048,95% CI:-0.075--0.021) and showed no significant association with LVMI and LVEF (P>0.05). Stratified analysis indicated that systolic blood pressure and baPWV had an interaction effect on LVEDd and mitral e′/a′<1(P<0.05). Conclusion BaPWV is associated with left ventricular remodeling and diastolic function. The correlation between baPWV and LVPW and LVEDd is stronger in groups with normal systolic blood pressure. In contrast, the correlation with mitral e′/a′<1 is more prominent in groups with elevated systolic blood pressure. |
| keywords:Brachial-ankle pulse wave velocity Transthoracic echocardiography Left ventricular structure Left ventricular function |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
