| 重症肺炎合并感染性休克患者血清STAT1、STAT3与预后的关系研究 |
| 投稿时间：2025-03-21 修订日期：2025-03-28 点此下载全文 |
| 引用本文：袁慧敏,王雷,丁艳芬,董锦秀,刘芳芳.重症肺炎合并感染性休克患者血清STAT1、STAT3与预后的关系研究[J].医学研究杂志,2025,54(9):109-113, 168 |
| DOI：
10.11969/j.issn.1673-548X.2025.09.019 |
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| 基金项目:上海市科学技术委员会资助项目(22Y11620800) |
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| 中文摘要:目的 探讨重症肺炎(severe pneumonia,SP)合并感染性休克(septic shock,SS)患者血清信号转导及转录激活蛋白(signal transducer and activator of transcription,STAT)1、STAT3与预后的关系。方法 按照1∶1的比例选取2021年1月~2023年10月上海交通大学医学院附属第九人民医院收治的SP合并SS患者105例(SP合并SS组)和健康体检志愿者105例(对照组),根据SP合并SS组患者28天预后分为死亡组和存活组。采用酶联免疫吸附试验检测血清STAT1、STAT3水平,多因素Logistic回归和受试者工作特征曲线分析血清STAT1、STAT3水平与SP合并SS患者预后的关系及预测价值。结果 与对照组比较,SP合并SS组血清STAT1、STAT3水平升高(P＜0.05)。SP合并SS患者入院28天死亡率为47.62%(50/105)。与存活组比较,死亡组血清STAT1、STAT3水平升高(P＜0.05)。序贯器官衰竭评估评分增加、急性生理学和慢性健康评估状况评价Ⅱ评分增加、STAT1升高、STAT3升高为SP合并SS患者死亡的独立危险因素(P＜0.05)。血清STAT1、STAT3水平单独及联合预测SP合并SS患者死亡的曲线下面积为0.778、0.787、0.880。经DeLong检验,血清STAT1、STAT3水平联合预测的曲线下面积更大(P＜0.05)。结论 SP合并SS患者血清STAT1、STAT3水平升高与死亡有关,两者联合检测对预后的预测价值较高。 |
| 中文关键词:重症肺炎 感染性休克 信号转导及转录激活蛋白1 信号转导及转录激活蛋白3 预后 相关性 |
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| Relationship between Serum STAT1, STAT3 and Prognosis in Patients with Severe Pneumonia Complicated with Septic Shock |
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| Abstract:Objective To investigate the relationship between serum signal transducer and activator of transcription protein (STAT) 1, STAT3 levels and prognosis in patients with severe pneumonia (SP) complicated with septic shock (SS). Methods A total of 105 patients with SP complicated with SS (SP+SS group) and 105 healthy physical examination volunteers (control group) admitted to Shanghai Ninth Poople′s Hospital, Shanghal JiaoTong University School of Medicine from January 2021 to October 2023 were selected in a 1:1 ratio. Based on the 28-day prognosis, the patients in the SP+SS group were divided into the survival group and the death group. Serum STAT1 and STAT3 levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression and receiver operating characteristic curve analyses were performed to assess the relationship between serum STAT1, STAT3 levels and prognosis, as well as their predictive value. Results Compared with the control group, the levels of serum STAT1 and STAT3 were significantly higher in the SP+SS group (P<0.05). The 28-day mortality of SP+SS patients was 47.62% (50/105) after admission. Compared with the survival group, the levels of serum STAT1 and STAT3 were significantly higher in the death group (P<0.05). Higher sequential organ failure assessment scores, increased acute physiology and chronic health evaluation Ⅱ scores, elevated STAT1, and elevated STAT3 were identified as independent risk factors for death in SP+SS patients (P<0.05). The area under the curve (AUC) for predicting the death of patients with SP+SS by serum STAT1, STAT3 levels alone, and their combined prediction were 0.778,0.787 and 0.880, respectively. The DeLong test showed that the AUC for the combined prediction was significantly higher than that of STAT1 or STAT3 levels alone (P<0.05). Conclusion Elevated serum STAT1 and STAT3 levels are associated with increased mortality in SP+SS patients, and their combined detection has high predictive value for prognosis. |
| keywords:Severe pneumonia Septic shock Signal transducer and activator of transcription protein 1 Signal transducer and activator of transcription protein 3 Prognosis Correlation |
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