| 中老年人身体形态指数与骨密度、骨质疏松和骨折风险的关系:基于NHANES 2017~2020年的数据分析 |
| 投稿时间：2025-04-21 修订日期：2025-05-04 点此下载全文 |
| 引用本文：罗杰华,高昊泽,刘奇沛,龚春柱.中老年人身体形态指数与骨密度、骨质疏松和骨折风险的关系:基于NHANES 2017~2020年的数据分析[J].医学研究杂志,2025,54(9):128-134 |
| DOI：
10.11969/j.issn.1673-548X.2025.09.022 |
| 摘要点击次数: 28 |
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| 基金项目:深圳市“医疗卫生三名工程”项目资助(SZZYSM202311020) |
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| 中文摘要:目的 探讨身体形态指数(a body shape index,ABSI)与骨密度、骨质疏松及骨折风险之间的关系,分析其作为中老年人骨骼健康风险预测指标的潜在价值,为骨质疏松和骨折的早期筛查及干预提供科学依据。方法 基于国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)2017~2020年的数据,选取年龄≥50岁的中老年人作为研究对象。计算ABSI值并按四分位数分类。通过逻辑回归模型分析ABSI与骨折风险的关系,并调整人口学特征、生活方式和临床相关因素的影响。同时,采用限制性立方样条(restricted cubic spline, RCS)模型探索ABSI与骨折风险的剂量-反应关系,并进行亚组分析以识别潜在的影响修饰因素。结果 随着ABSI四分位数的升高,骨密度逐渐降低,骨质疏松及骨折风险显著增加(趋势P<0.05)。与ABSI最低四分位数比较,最高四分位数的骨折风险显著增加(调整后OR为1.33,95% CI:1.04~1.70)。RCS分析显示,ABSI与骨折风险呈线性正相关(整体P<0.001),骨折风险随着ABSI水平的升高而逐渐增加。亚组分析结果显示,这一关联在不同年龄、性别和体重指数(body mass index,BMI)类别中具有一致性。结论 ABSI与较低的骨密度、较高的骨质疏松及骨折风险独立相关。这表明,ABSI是一种简便有效的工具,可用于筛查骨骼健康风险较高的人群,为骨质疏松及骨折的早期预防和干预策略提供科学依据。 |
| 中文关键词:身体形态指数 骨密度 骨质疏松 骨折风险 骨骼健康 NHANES |
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| Relationship Between A Body Shape Index, Bone Mineral Density, Osteoporosis, and Fracture Risk in Middle-aged and Elderly Adults:Evidence from NHANES 2017-2020 |
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| Abstract:Objective To investigate the relationship between a body shape index (ABSI), bone mineral density (BMD), osteoporosis, and fracture risk, and to evaluate its potential value as a predictive marker for skeletal health risks in middle-aged and elderly individuals. This study aims to provide scientific evidence for the early screening and intervention of osteoporosis and fracture risks. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020, individuals aged ≥50 years were selected as the study population. ABSI was calculated and categorized into quartiles. The relationship between ABSI and fracture risk was analyzed using logistic regression models while adjusting for demographic characteristics, lifestyle factors, and clinical variables. A restricted cubic spline (RCS) model was employed to explore the dose-response relationship between ABSI and fracture risk. Subgroup analyses were conducted to identify potential effect modifiers. Results BMD decreased, and the risks of osteoporosis and fractures significantly increased with higher ABSI quartiles (trend P<0.05). Compared to the lowest ABSI quartile, individuals in the highest quartile had a significantly increased fracture risk (adjusted OR=1.33,95% CI:1.04-1.70). RCS analysis demonstrated a linear positive correlation between ABSI and fracture risk (overall P < 0.001), with fracture risk progressively increasing with higher ABSI levels. Subgroup analyses revealed consistent associations across different age groups, sexes, and BMI categories. Conclusion ABSI is independently associated with lower BMD, higher osteoporosis risk, and increased fracture risk. These findings suggest that ABSI is a simple and effective tool for identifying individuals at high skeletal health risk, providing scientific evidence for the early prevention and intervention of osteoporosis and fractures. |
| keywords:A Body Shape Index Bone mineral density Osteoporosis Fracture risk Skeletal health NHANES |
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