| 糖尿病视网膜病变中医证型与TyG指数的相关性 |
| 投稿时间：2025-05-07 修订日期：2025-05-17 点此下载全文 |
| 引用本文：万世媚,李沙沙,王晓赐,赵越.糖尿病视网膜病变中医证型与TyG指数的相关性[J].医学研究杂志,2025,54(10):53-57 |
| DOI：
10.11969/j.issn.1673-548X.2025.10.010 |
| 摘要点击次数: 170 |
| 全文下载次数: 64 |
|
| 基金项目:江苏省自然科学基金资助项目(BK20191090)；江苏省中医药科技发展计划重点项目(ZD202406)；新疆维吾尔自治区卫生健康委员会科研项目(2025001CXKYXM653022933) |
|
| 中文摘要:目的 探讨糖尿病视网膜病变(diabetic retinopathy,DR)中医证型与甘油三酯葡萄糖(triglyceride-glucose, TyG)指数的关系。方法 对2019年1～10月江苏省中医院住院的185例DR患者进行中医辨证分型,比较不同中医证型患者临床资料的差异,采用Logistic回归分析评价中医证型与TyG指数之间的关系。结果 185例DR患者证型分布情况为阴虚燥热证32例(17.3%),气阴两虚证61例(33.0%),肝肾亏虚证35例(18.9%),脾虚湿滞证28例(15.1%),阴阳两虚证29例(15.7%)。各证型在TyG指数、空腹血糖(asting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)方面比较,差异均有统计学意义(P<0.05)。脾虚湿滞证患者的TyG指数、TG水平高于其他4组(P<0.05)。气阴两虚证和脾虚湿滞证患者的FBG水平高于阴阳两虚证(P<0.05)。气阴两虚证患者的HbA1c水平高于其他4组(P <0.05)。脾虚湿滞证患者的HDL-C水平低于气阴两虚证,阴阳两虚证患者的HDL-C水平低于肝肾亏虚证(P<0.05)。Logistic回归分析结果显示,TyG指数与脾虚湿滞证呈正相关,是脾虚湿滞证的独立危险因素。结论 DR最常见的中医证型是气阴两虚证,TyG指数在脾虚湿滞证患者中最高,可作为DR中医辨证分型的客观辅助指标。 |
| 中文关键词:糖尿病视网膜病变 TyG指数 中医证型 相关性 |
| |
| Correlation between TCM Syndromes and TyG Index in Diabetic Retinopathy. |
|
|
| Abstract:Objective To investigate the relationship between traditional Chinese medicine (TCM) syndromes and triacylglyceride-glucose (TyG) index in diabetic retinopathy (DR). Methods A total of 185 DR patients hospitalized in Jiangsu Provincial Hospital of Traditional Chinese Medicine from January to October 2019 were classified by TCM syndromes differentiation, the differences in clinical data of patients with different TCM syndromes were compared, and the correlation between each TCM syndromes and TyG index was analyzed by Logistic regression. Results The distribution of the 185 DR patients was 32 cases (17.3%) with syndrome of yin deficiency and internal heat, 61 cases (33.0%) with syndrome of qi-yin deficiency, 35 cases (18.9%) with syndrome of liver-kidney deficiency, 28 cases (15.1%) with syndrome of spleen deficiency and dampness retention, and 29 cases (15.7%) with syndrome of yin-yang deficiency. Statistically significant differences were observed in TyG index, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) among different syndromes (P<0.05). Patients with syndrome of spleen deficiency and dampness retention had significantly higher TyG index and TG levels than those in the other four groups (P<0.05). FBG levels in patients with syndrome of qi-yin deficiency and syndrome of spleen deficiency and dampness retention were higher than those in patients with syndrome of yin-yang deficiency (P<0.05). HbA1c levels in patients with syndrome of qi-yin deficiency were significantly higher than those in the other four groups (P<0.05). HDL-C levels in the spleen deficiency with dampness stagnation group were lower than those in the qi-yin deficiency group, and HDL-C levels in the yin-yang deficiency group were lower than those in the liver-kidney deficiency group (P<0.05). The results of Logistic regression analysis showed that the TyG index was positively correlated with syndrome of spleen deficiency and dampness retention, and served as an independent risk factor for this syndrome. Conclusion The most common TCM syndrome in DR patients is syndrome of qi-yin deficiency. The TyG index is highest in patients with syndrome of spleen deficiency and dampness retention, indicating its potential as an objective auxiliary indicator for TCM syndrome differentiation in DR. |
| keywords:Diabetic retinopathy TyG index TCM syndrome type Correlation |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
