| 脑脊液IL-6和IL-10对原发性眼内淋巴瘤预后的预测价值 |
| 投稿时间：2025-04-25 修订日期：2025-06-09 点此下载全文 |
| 引用本文：孙文杰,张薇.脑脊液IL-6和IL-10对原发性眼内淋巴瘤预后的预测价值[J].医学研究杂志,2025,54(10):105-109 |
| DOI：
10.11969/j.issn.1673-548X.2025.10.019 |
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| 中文摘要:目的 分析脑脊液白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)对原发性眼内淋巴瘤(primary intraocular lymphoma,PIOL)患者预后的预测价值。方法 采用回顾性研究方法,选取2018年1月~2022年12月中国医学科学院/北京协和医学院北京协和医院收治的60例PIOL患者,出院后随访2年进行预后评估,统计不良预后发生率。将发生不良预后的患者纳入预后不良组,将未发生不良预后的患者纳入预后良好组,对比两组入院时的临床资料。采用多因素Logistic回归分析评价脑脊液IL-6、IL-10对预后的影响。绘制受试者工作特征(receiver operating characteristic,ROC)曲线,分析脑脊液IL-6、IL-10对预后的预测价值。结果 60例患者随访2年后,22例出现不良预后,不良预后发生率为36.67%。预后不良组22例,预后良好组38例；2组的脑脊液IL-6、IL-10比较,差异均有统计学意义(P＜0.05)。多因素Logistic回归分析结果显示,脑脊液IL-6、IL-10是PIOL患者不良预后的危险因素。脑脊液IL-6、IL-10联合检测对预后预测的曲线下面积(area under the curve,AUC)、敏感度、特异性分别为0.879、85.53%、91.46%,高于脑脊液IL-6、IL-10单项检测。结论 脑脊液IL-6、IL-10对PIOL患者预后具有一定的预测价值,高IL-6、IL-10水平提示预后不良。 |
| 中文关键词:脑脊液 IL-6 IL-10 原发性眼内淋巴瘤 预后 预测价值 |
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| Prognostic Value of Cerebrospinal Fluid IL-6 and IL-10 for the Prognosis of Primary Intraocular Lymphoma. |
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| Abstract:Objective To analyze the predictive value of cerebrospinal fluid interleukin-6 (IL-6) and interleukin-10 (IL-10) in the prognosis of patients with primary intraocular lymphoma (PIOL). Methods A retrospective study was conducted, 60 PIOL patients admitted to Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital from January 2018 to December 2022 were selected. Follow-up assessments were conducted for 2 years after discharge to evaluate the prognosis and calculate the incidence of adverse outcomes. Patients with adverse outcomes were classified as the poor prognosis group, while those without adverse outcomes were classified as the good prognosis group. Clinical data at admission were compared between the two groups. Multivariate Logistic regression analysis was used to assess the impact of cerebrospinal fluid IL-6 and IL-10 on prognosis. Receiver operating characteristic (ROC) curve were plotted to evaluate the predictive value of cerebrospinal fluid IL-6 and IL-10 for prognosis. Results After 2 years follow-up of 60 patients, 22 patients developed adverse outcomes, with an incidence rate of 36.67%. The poor prognosis group included 22 patients, while the good prognosis group included 38 patients. There were statistically significant difference in cerebrospinal fluid IL-6 and IL-10 between the two groups (P<0.05). The results of multivariate Logistic regression analysis indicated that cerebrospinal fluid IL-6 and IL-10 were risk factors for adverse outcomes. The area under the curve (AUC), sensitivity, and specificity of the combined detection of IL-6 and IL-10 in cerebrospinal fluid for predicting prognosis were 0.879,85.53% and 91.46%, respectively, which were higher than those of single detections of IL-6 or IL-10 in cerebrospinal fluid. Conclusion The combined detection of IL-6 and IL-10 in cerebrospinal fluid has a certain predictive value for the prognosis of PIOL patients, with high levels of IL-6 and IL-10 indicating a poor prognosis. |
| keywords:Cerebrospinal fluid IL-6 IL-10 Primary intraocular lymphoma Prognosis Predictive value |
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