| CONUT评分对糖尿病视网膜病变影响的性别差异 |
| 投稿时间：2025-05-07 修订日期：2025-05-26 点此下载全文 |
| 引用本文：韩宇南,王金丽,王勇翔,肖醉萱.CONUT评分对糖尿病视网膜病变影响的性别差异[J].医学研究杂志,2025,54(10):110-116, 127 |
| DOI：
10.11969/j.issn.1673-548X.2025.10.020 |
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| 中文摘要:目的 探讨控制营养状况(controlling nutritional status, CONUT)评分与糖尿病视网膜病变(diabetic retinopathy, DR)之间的关联,并分析其在不同性别2型糖尿病(type 2diabetes mellitus, T2DM)患者中的差异,评估CONUT评分作为DR营养状态评估工具的临床应用价值。方法 回顾性分析2022年1月～2024年9月长江大学附属第一医院收治的1526例T2DM患者的临床资料。根据患者是否患有DR,分为DR组(n=587)和非DR组(n=939)。收集患者的性别、年龄、文化程度、实验室指标等临床资料,并计算CONUT评分。采用多因素Logistic回归模型和限制性立方样条(restricted cubic spline, RCS)评估CONUT评分与DR的关系,并进行了性别分层分析和亚组分析。结果 CONUT评分与DR风险呈显著正相关。调整所有协变量后,较高的CONUT评分与男性患者DR风险呈显著正相关(OR=1.215,95%CI:1.030~1.438)；RCS分析结果显示,CONUT评分与总人口(P非线性=0.247)和男性(P非线性=0.466)DR风险之间呈线性正相关。亚组分析结果显示,年龄＜60岁、高中学历、无心血管疾病、体重指数＜25kg/m2及不使用降糖药的男性DR患者中,CONUT评分对DR风险的影响更为显著。结论 CONUT评分在男性T2DM患者中能够有效评估DR风险,显示出其在临床实践中的应用价值。 |
| 中文关键词:2型糖尿病 糖尿病视网膜病变 CONUT评分 性别差异 营养评估 |
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| Gender Differences in the Impact of CONUT Score on Diabetic Retinopathy. |
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| Abstract:Objective To explore the association between the controlling nutritional status (CONUT) score and diabetic retinopathy (DR), and analyze gender differences in this relationship among type 2 diabetes mellitus (T2DM) patients, assessing the clinical application value of the CONUT score as a tool for evaluating nutritional status in DR. Methods A retrospective analysis was conducted on the clinical data of 1526 patients with T2DM admitted to the First Affiliated Hospital of Yangtze University from January 2022 to September 2024. The patients were categorized into the DR group (n=587) and the non-DR group (n=939) based on the presence of DR. Clinical data such as gender, age, educational level, and laboratory parameters were collected, and CONUT scores were calculated. Multivariate Logistic regression model and restricted cubic splines (RCS) were employed to assess the relationship between CONUT scores and DR, with stratified and subgroup analyses performed based on gender. Results A significant positive association was found between CONUT scores and the risk of DR. After adjusting for all covariates, higher CONUT scores were significantly associated with an increased risk of DR in male patients (OR=1.215,95% CI:1.030-1.438). The RCS results indicated a linear positive association between CONUT scores and the risk of DR in the general population (Pnonlinear=0.247) and males (Pnonlinear=0.466). Subgroup analysis revealed that the effect of CONUT scores on the risk of DR risk was more pronounced in male patients who were under 60 years of age, had a high school education, did not have cardiovascular disease, had a body mass index below 25kg/m2, and were not using hypoglycemic agents. ConclusionThe CONUT score effectively assesses the risk of DR in male T2DM patients, demonstrating its application value in clinical practice. |
| keywords:Type 2diabetes Diabetic retinopathy CONUT score Gender differences Nutritional assessment |
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