| 基于中医传承辅助平台的名中医治疗慢性乙肝后肝硬化临床用药经验 |
| 投稿时间：2025-06-25 修订日期：2025-07-03 点此下载全文 |
| 引用本文：向慧儿,张玉佩,杨钦河.基于中医传承辅助平台的名中医治疗慢性乙肝后肝硬化临床用药经验[J].医学研究杂志,2025,54(11):46-50 |
| DOI：
10.11969/j.issn.1673-548X.2025.11.010 |
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| 基金项目:国家自然科学基金资助项目(面上项目)(82374230)；国家中医药管理局全国名老中医传承工作室建设项目{国中医药人教函[2022]75号}；广东省自然科学基金资助项目(面上项目)(2021A1515012173,2022A1515011577)；广东省中医药局科研项目(20231348) |
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| 中文摘要:目的 探讨杨钦河教授临床辩证治疗慢性乙型肝炎肝硬化(post-hepatitis B cirrhosis, PHBC)的经验,以指导临床实践和新药开发。方法 收集杨钦河教授治疗PHBC的医案,基于中医传承辅助平台(V3.5)分析处方药物频次、核心组合及药物关联规则。结果 共纳入181则医案,涉及中药3119次。高频药物包括当归、丹参、赤芍、党参、炙鳖甲、柴胡、陈皮、黄芪、枸杞子、茵陈,药性以寒、温为主,药味以甘、苦居多,归经主要属肝、脾。用药模式分析得到10种核心药材,共生成252种药对,频次最高的为赤芍-当归。关联规则分析共获得249条关联规则,置信度为1的有赤芍、黄芪、枸杞子→丹参及赤芍、黄芪、当归、枸杞子→丹参。结论 杨钦河教授在辩证论治PHBC时,重视从血分论治,指出“活血祛瘀养血”是治疗PHBC的常用治法和主要措施,强调维持肝脾功能协调,配合清除病毒、清热化湿、养肝益肾等治疗策略。 |
| 中文关键词:慢性乙肝后肝硬化 名中医 学术经验 中医传承辅助平台 |
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| Clinical Medication Experience of Famous Chinese Medicine Practitioners in the Treatment of Chronic Post-hepatitis B Cirrhosis Based on the Traditional Chinese Medicine Inheritance Support Platform. |
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| Abstract:Objective To explore the experience of Professor Yang Qinhe in the clinical dialectical treatment of post-hepatitis B cirrhosis (PHBC), in order to guide clinical practice and new drug development. Methods Medical records of PHBC treated by Professor Yang Qinhe were collected. The frequency of prescription drugs, core combinations and drug association rules were analyzed based on the Traditional Chinese Medicine Inheritance Support Platform (V3.5). Results A total of 181medical records were included, involving 3119 uses of traditional Chinese medicines. The high-frequency drugs included Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Codonopsis, Cooked Carapax Trionycis, Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Astragali, Fructus Lycii, and Herba Artemisiae Scopariae. The properties of the drugs were mainly cold and warm, and the flavors were mostly sweet and bitter. The meridians mainly involved the liver and spleen. The analysis of the drug usage patterns yielded 10 core medicinal materials, generating a total of 252drug pairs, with the highest frequency being Radix Paeoniae Rubra-Radix Angelicae Sinensis. Association rule analysis yielded 249 association rules, with confidence of 1 for Radix Paeoniae Rubra, Radix Astragali, Fructus Lycii→Radix Salviae Miltiorrhizae, and Radix Paeoniae Rubra, Radix Astragali, Radix Angelicae Sinensis, Fructus Lycii→Radix Salviae Miltiorrhizae. Conclusion Professor Yang Qinhe emphasizes treating PHBC from the perspective of blood, suggesting that "activating blood, removing blood stasis and nourishing blood" is a common and primary treatment approach. He also emphasizes maintaining the coordination of liver and spleen functions, and combines this with strategies such as virus clearance, heat-clearing and dampness-removing, and liver and kidney nourishment. |
| keywords:Post-hepatitis B cirrhosis Famous Chinese medicine practitioner Academic experience Traditional Chinese Medicine Inheritance Support Platform |
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