| 代谢综合征及其组分与甲状腺结节的因果关系: 一项孟德尔随机化研究 |
| 投稿时间：2025-03-02 修订日期：2025-05-12 点此下载全文 |
| 引用本文：闫军浩,傅聿铭,杨战锋,罗昭锋,唐坚,王争.代谢综合征及其组分与甲状腺结节的因果关系: 一项孟德尔随机化研究[J].医学研究杂志,2025,54(11):51-55, 62 |
| DOI：
10.11969/j.issn.1673-548X.2025.11.011 |
| 摘要点击次数: 35 |
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| 基金项目:国家自然科学基金资助项目(面上项目)(82270552)；河南省医学科技攻关计划省部共建重点项目(SBGJ202102184) |
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| 中文摘要:目的 采用两样本孟德尔随机化(Mendelian randomization, MR)的方法,分析代谢综合征(metabolic syndrome, MetS)及其各组分与甲状腺结节(thyroid nodule, TN)之间的因果关系。方法 从公开的全基因组关联研究(Genome-Wide Association Studies, GWAS)数据库中获取MetS及其各组分和TN的汇总数据集,选取与MetS及其各组分强相关的单核苷酸多态性(single nucleotide polymorphism, SNP)作为工具变量。采用MR-Egger回归法、逆方差加权(inverse variance weighted, IVW)法、基于汇总数据的广义孟德尔随机化(generalized summary-data-based Mendelian randomization v2,GSMR2)法,评估MetS及其各组分与TN发生风险之间的因果关系。IVW法作为MR分析的主要方法。通过Cochran′s Q检验、MR-Egger截距检验及留一法(leave-one-out)进行敏感度分析,以评估研究结果的可靠性和稳定性。结果 IVW法分析结果显示,遗传预测的MetS(P=0.009,OR=1.186,95% CI:1.044～1.346)和腰围(P=0.008,OR=1.158,95% CI:1.040～1.290)与TN发生风险增加存在潜在的因果关系。未发现收缩压、舒张压、甘油三酯、高密度脂蛋白胆固醇、空腹血糖与TN之间存在因果关系。敏感度分析显示,研究结果不受异质性和多效性影响。结论 MR分析结果表明,MetS及其组分腰围是TN发生的潜在危险因素。 |
| 中文关键词:代谢综合征 腰围 向心性肥胖 甲状腺结节 孟德尔随机化 |
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| Causal Relationship Between Metabolic Syndrome and Its Components with Thyroid Nodule:A Mendelian Randomization Study. |
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| Abstract:Objective To analyze the causal relationship between metabolic syndrome (MetS) and its components with thyroid nodule (TN) by using a two-sample Mendelian randomization (MR) approach. Methods Summary-level datasets for MetS, its components, and TN were obtained from publicly available Genome-Wide Association Studies (GWAS) databases. Single nucleotide polymorphism (SNP) strongly associated with MetS and its components were selected as instrumental variables. The causal relationships between MetS and its components with the risk of TN were assessed using MR-Egger regression, inverse variance weighted (IVW) method, and generalized summary-data-based Mendelian randomization v2 (GSMR2). The IVW method served as the primary approach for MR analysis. Sensitivity analyses, including Cochran′s Q test, MR-Egger intercept test, and leave-one-out analysis, were conducted to evaluate the reliability and stability of the results. Results IVW method analysis revealed that genetically predicted MetS (P=0.009, OR=1.186,95% CI:1.044-1.346) and waist circumference (P=0.008, OR=1.158,95% CI:1.040-1.290) were potentially associated with an increased risk of TN. No causal relationships were found between systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, fasting blood glucose and TN. Sensitivity analyses indicated that the results were not influenced by heterogeneity or pleiotropy. Conclusion The results of the MR analysis suggest that MetS and its component, waist circumference, are potential risk factors for the development of TN. |
| keywords:Metabolic syndrome Waist circumference Central obesity Thyroid nodule Mendelian randomization |
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