| 三阴性乳腺癌患者新辅助化疗后达到病理完全缓解的影响因素分析 |
| 投稿时间：2025-03-25 修订日期：2025-07-08 点此下载全文 |
| 引用本文：徐梦,孙全武,黄海云,史琴英,马佩兰,吕凤燕.三阴性乳腺癌患者新辅助化疗后达到病理完全缓解的影响因素分析[J].医学研究杂志,2025,54(11):95-99 |
| DOI：
10.11969/j.issn.1673-548X.2025.11.018 |
| 摘要点击次数: 45 |
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| 基金项目:甘肃省自然科学基金资助项目(22JR5RA691)；甘肃省卫生行业科研计划项目(GSWSKY2016-32) |
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| 中文摘要:目的 探讨三阴性乳腺癌(triple-negative breast cancer, TNBC)患者新辅助化疗(neoadjuvant chemotherapy, NAC)后达到病理完全缓解(pathological complete response, pCR)的影响因素。方法 回顾性选取2018年8月~2024年6月就诊于甘肃省人民医院乳腺科的NAC后达到pCR的62例TNBC患者为研究组,选取同期NAC后未达到pCR的98例TNBC患者为对照组,结合其临床、病理、免疫组化的特征以及外周血相关指标,分析TNBC患者NAC后达到pCR的影响因素。结果 单因素分析中,χ2检验结果显示,研究组与对照组患者的年龄、月经状态、病理类型、肿瘤直径、腋窝淋巴结转移、组织学分级以及p53等指标比较,差异均有统计学意义(P＜0.05)；t检验结果显示,研究组与对照组患者的中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio, NLR)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-C)、CA-153、D-二聚体水平比较,差异均有统计学意义(P＜0.05)。多因素Logistic回归分析结果显示,年龄(OR=1.122,95%CI:1.009~1.409)、月经状态(OR=0.112,95%CI:0.026~0.483)、肿瘤直径(OR=0.401,95%CI:0.189~0.849)、p53(OR=4.950,95%CI:1.160~21.125)、NLR(OR=0.506,95%CI:0.259~0.989)、LDL-C(OR=0.099,95%CI:0.036~0.272)、CA-153(OR=0.840,95%CI:0.769~0.917)等是TNBC患者NAC后达到pCR的独立影响因素。结论 年龄、月经状态、肿瘤直径、p53、NRL、LDL-C以及CA-153是TNBC患者NAC后达到pCR的独立影响因素。 |
| 中文关键词:三阴性乳腺癌 新辅助化疗 病理完全缓解 |
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| Analysis of Influencing Factors for Achieving Pathological Complete Response after Neoadjuvant Chemotherapy in Patients with Triple-negative Breast Cancer. |
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| Abstract:Objective To investigated the influencing factors for achieving pathological complete response (pCR) in patients with triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NAC). Methods A retrospective study was conducted to collect 62 patients with TNBC who achieved pCR after NAC from August 2018 to June 2024 at the Department of Breast Surgery, Gansu Provincial Hospital, and 98 patients with TNBC who did not achieve pCR as the control group. The clinical, pathological, and immunohistochemical features, as well as the peripheral blood related indicators, were analyzed to investigate the influencing factors for achieving pCR in patients with TNBC after NAC. Results In the univariate analysis, the results of χ2 test showed that there were statistically significant differences in indicators such as age, menstrual status, pathological type, tumor size, axillary lymph node metastasis, histological grade, and p53 between the study group and the control group (P<0.05). The results of t-test showed that there were statistically significant differences in neutrophil-to-lymphocyte ratio (NLR), low-density lipoprotein cholesterol (LDL-C), CA-153, and D-dimer levels between the study group and the control group (P<0.05). The results of multivariate Logistic regression analysis showed that age (OR=1.122,95%CI:1.009-1.409), menstrual status (OR=0.112,95%CI:0.026-0.483), tumor size (OR=0.401,95%CI:0.189-0.849), p53 (OR=4.950,95%CI:1.160-21.125), NLR (OR=0.506,95%CI:0.259-0.989), LDL-C (OR=0.099,95%CI:0.036-0.272), and CA-153 (OR=0.840,95%CI:0.769-0.917) were independent influencing factors for achieving pCR after NAC in patients with TNBC. Conclusion Age, menstrual status, tumor size, p53, NLR, LDL-C, and CA-153 are independent influencing factors for achieving pCR after NAC in patients with TNBC. |
| keywords:Triple-negative breast cancer Neoadjuvant chemotherapy Pathological complete response |
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