| 乌药精颗粒对小鼠免疫功能影响的实验研究 |
| 投稿时间：2009-09-11 修订日期：2009-12-03 点此下载全文 |
| 引用本文：戴关海、吴人照、杨锋、童晔玲、陈宇.乌药精颗粒对小鼠免疫功能影响的实验研究[J].医学研究杂志,2010,39(1):43-46 |
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| 基金项目:浙江省科技厅开发专项资助项目（2006F13015） |
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| 中文摘要:目的观察乌药精颗粒对小鼠免疫功能的影响。方法实验设乌药精颗粒低、中、高3个剂量组(1.0g/kg、2.0g/kg和6.0g/kg，分别相当于人推荐量的5、10、30倍) ，另设乌药组（0.9g/kg）、别直参组（2.0g/kg）及阴性对照组(H2O)，经口给予30天。分别观察ConA 诱导的小鼠脾淋巴细胞增生功能、对二硝基氟苯诱导小鼠迟发型变态反应、抗体生成细胞、血清溶血素含量及NK细胞活性的影响。结果高、低剂量组乌药精颗粒均可明显提高ConA 诱导的小鼠脾淋巴细胞增生功能，与阴性对照组比较有明显差异（P＜0.05、0.01）；乌药精颗粒高剂量组可明显提高对二硝基氟苯诱导小鼠迟发型变态反应功能，与阴性对照组比较有明显差异（P＜0.05）；各剂量组乌药精颗粒对小鼠抗体生成细胞、血清溶血素含量及NK细胞活性均无明显差异(P＞005)。结论乌药精颗粒可明显提高小鼠 ConA 诱导的小鼠脾淋巴细胞的增生功能及二硝基氟苯诱导小鼠迟发型变态反应功能。 |
| 中文关键词:乌药精颗粒、小鼠、免疫功能、实验研究 |
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| Experimental Study of the Effect of Wuyaojing Granules on the Immunological Function of Mice |
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| Abstract:ObjectiveTo observe the effect of Wuyaojing granules(WYJG) on immunological function of mice.MethodsMice were randomly divided into six groups：the high-dosage WYJG group(6.0g/kg)，the midst-dosage WYJG group (2.0g/kg)，the low-dosage WYJG group(1.0g/kg)，the Lindera aggregate group (0.9g/kg)，the korean Ginseng group (2.0g/kg) and the normal control group(H2O).After a period of 30-day treatment，the effects of WYJG on the T lymphocyte transformations capacity induced by ConA，delayed hypersensitivity leaded by DNFB，the number of lymphocyte B，serum level of hemolysin and NK activity were observed. ResultsThe high-dosage and the low-dosage WYJG could significantly increase T lymphocyte transformations capacity induced by ConA（P＜005～0.01）. The high-dosage WYJG could strengthen delay hypersensitivity leaded by DNFB（P<0.05）. And The WYJG could not affect the number of lymphocyte B，serum level of hemolysin and NK activity(P＞0.05).ConclusionWYJG can significantly increase T lymphocyte transformations capacity induced by ConA and strengthen delay hypersensitivity leaded by DNFB. |
| keywords:Wuyaojing granules Mice Immunological function Experimental study |
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