| 槲皮素在HPV阳性的ASCUS患者中的临床应用 |
| 投稿时间：2010-03-15 点此下载全文 |
| 引用本文：周琦,张蔚,陈娇,雷曼殊,江敬红,熊霞鹂.槲皮素在HPV阳性的ASCUS患者中的临床应用[J].医学研究杂志,2010,39(8):54-56 |
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| 基金项目:湖北省科技厅资助项目（2007AA301B33-2） |
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| 中文摘要:目的探讨槲皮素在HPV阳性的宫颈鳞状上皮不典型增生（ASCUS）患者中的临床应用效果。方法以宫颈癌高发区湖北五峰为试验点。使用TCT和HC-2筛查高危型HPV感染阳性的ASCUS患者90名，随机选取45名为实验组，另外45名为对照组。用中药槲皮素宫颈局部上药，6个月后复查，采用TCT和HC-2检测用药前后宫颈细胞学的变化以及高危型HPV阳性患者例数的改变。结果槲皮素治疗后，经TCT筛查，实验组正常患者38例，总有效率为84.4%。对照组正常患者20例，总有效率为44.4%。比较两组间差异有统计学意义（P<0.05）。HC-2检测高危型HPV感染阳性例数的改变，实验组转阴30例，转阴率为66.7%，对照组转阴16例，转阴率为35.6%。比较两组间差异有统计学意义（P<0.05）。结论槲皮素对HPV阳性的ASCUS患者有较明显的疗效。 |
| 中文关键词:槲皮素 HPV ASCUS |
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| The Clinical Application of Quercetin in the HPV-positive ASCUS Patients |
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| Abstract:ObjectiveTo discuss the clinical application effect of quercetin in the HPV-positive cervical squamous epithelial dysplasia (ASCUS) patients.MethodsOur test sites were in the high incidence area of cervical cancer in Hubei Wufeng. There were 90 patients in high-risk HPV-positive ASCUS infection screening by TCT and HC-2,of which 45,called the experimental group, were randomly selected,and another 45, called the control group.Traditional Chinese medicine drug quercetin was used on the cervical part, and the results were review after 6 months.The changes in cervical cytology before and after treatment, as well as the changes in the number of cases of high-risk HPV-positive patients were detected using TCT and HC-2. ResultsAfter the treatment of quercetin, there were 38 cases in experimental group being normal by the TCT screening, and the total effective rate was 84.4%.But the control group only had 20 normal patients, with a total effective rate of 44.4%.There was statistically significant difference between the two groups (P<005).We used HC-2 to detect high-risk HPV-positive cases of infection and observe the number of changes,and we could find that the negative cases in the experimental group were 30, negative conversion rate was 66.7%, negative cases in the control group were 16,negative conversion rate was 356%.There was statistically significant difference between the two groups (P<005). ConclusionQuercetin has a more visible effect on HPV-positive ASCUS patients. |
| keywords:Quercetin HPV ASCUS |
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