| 甘油果糖与甘露醇治疗颅脑损伤后颅内高压临床观察 |
| 投稿时间：2010-03-26 点此下载全文 |
| 引用本文：邓仁益,樊弘毅,陈健.甘油果糖与甘露醇治疗颅脑损伤后颅内高压临床观察[J].医学研究杂志,2010,39(10):98-100 |
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| 中文摘要:目的观察甘露醇和甘油果糖对颅脑损伤后颅内高压的治疗效果。 方法86例脑挫裂伤、脑内血肿所致颅内高压非手术病人随机分为甘露醇组（44例），甘油果糖组（42例）。在出现颅内高压症状后，甘露醇组应用20%甘露醇125ml静脉滴注每6~8h 1次，连用5天后减量，疗程2周。甘油果糖组应用甘油果糖250ml静脉滴注每6~8h 1次，连用5天后减量，疗程2周。治疗前及治疗后5天，2周分别进行头部CT扫描，观察颅内高压临床症状的缓解及脑内水肿范围情况。结果治疗后5天甘露醇组头痛明显缓解率明显优于甘油果糖组（P<0.01）, 水肿范围的消退也优于甘油果糖组（P<0.05）。治疗后2周两组临床症状的缓解及脑内水肿范围情况无显著性差异（P>0.05）。结论甘露醇与甘油果糖均能缓解颅脑损伤后颅内高压，减轻脑水肿。对于颅脑损伤后颅内高压水肿高峰期更适用甘露醇治疗。 |
| 中文关键词:甘露醇 甘油果糖 颅脑损伤 颅内高压 |
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| Effects of Glycerol Fructose or Mannitol in Treating Intracranial Hypertension Induced by Craniocerebral Injury |
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| Abstract:ObjectiveTo observe the effects of glycerol fructose and mannitol in treating intracranial hypertension induced by craniocerebral injury. MethodsEighty-six patients with intracranial hypertension induced by contusion and laceration of brain and intracerebral hematoma were randomly divided into mannitol group (n=44) and glycerol fructose group(n=42). After onset of symptoms of intracranial hypertension, 20% mannitol 125ml and glycerol fructose were administered to corresponding patients respectively by intravenous drip every 6~8h, tapered down over 5 days with a course of 2 weeks. Head CT scanning was performed before treatment，5 days and 2 weeks after treatment to observe the remission of clinical symptoms of intracranial hypertension and the range change of cerebral edema. ResultsAfter 5-day treatment, remission rate in mannitol group was significantly higher than that in glycerol fructose group (P<001), and the same to edema range reduced (P<0.05). But after 2-week treatment, these differences were of no statistical significance（P>0.05）. ConclusionBoth mannitol and glycerin fructose could relieve intracranial hypertension and alleviate cerebral edema. Mannitol was more appropriate in crest time of the disease. |
| keywords:Mannitol Glycerol fructose Craniocerebral injury Intracranial hypertension |
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