| 电针对膝骨关节炎大鼠软骨bFGF表达的影响 |
| 投稿时间：2010-06-29 点此下载全文 |
| 引用本文：王道海,孙华,包飞,吴志宏,王凤琴,张云祥.电针对膝骨关节炎大鼠软骨bFGF表达的影响[J].医学研究杂志,2010,39(12):106-109 |
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| 中文摘要:目的探讨电针对骨关节炎(OA)软骨修复的影响。方法40只SD雌性大鼠随机分为正常组、模型组、治疗组、对照组各10只。采用单侧后肢跟腱切除法建立OA动物模型，即：切除右侧后肢跟腱，建立左侧后肢膝骨关节炎模型。术后4周对治疗组非手术侧（左侧）和对照组手术侧（右侧）膝关节采用电针治疗2周。实验第7周收集每只动物左侧膝关节股骨端软骨，组织病理切片行免疫组化染色，观察碱性成纤维细胞生长因子（bFGF）在软骨组织中表达的特点。结果治疗组软骨bFGF的表达增强，较其他三组有非常显著差异（P<0.01）。结论电针对OA大鼠膝关节软骨bFGF的表达具有上调作用，提示电针可能具有促进软骨修复作用。 |
| 中文关键词:电针 骨关节炎 碱性成纤维细胞生长因子 |
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| Influence of Electro-acupuncture on bFGF Expression in the Cartilage of Knee Osteoarthritic Rats |
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| Abstract:ObjectiveTo study the influence of electro-acupuncture on renovation of osteoarthritic cartilage. Methods40 female SD rats were randomly divided into four groups: the normal, model, treatment and control group. Using the method of heel tendon resection for unilateral hind limb, we established the OA animal model， that was cutting off the heel tendon of right hind limb to establish the knee OA model of left hind limb. The left knees(no operation side) of treatment group and right ones (operation side) of control group were treated by electro-acupuncture for two weeks from the fifth week since operation. We collected cartilage of all rats′ left knees at the seventh week since the beginning of experiment. We used immunohistochemical staining to observe bFGF expression in cartilage. ResultsbFGF expression in treatment group was very significantly stronger than the other three groups(P<0.01). ConclusionElectro-acupuncture up-regulates the level of bFGF in cartilage of knee osteoarthritic rats. It indicates that electro-acupuncture is probably effective in promoting cartilage renovation. |
| keywords:Electro-acupuncture Osteoarthritis bFGF |
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