| 孕妇感染甲型H1N1流感临床特征及妊娠结局分析 |
| 投稿时间：2010-07-08 点此下载全文 |
| 引用本文：孙文超,王志华.孕妇感染甲型H1N1流感临床特征及妊娠结局分析[J].医学研究杂志,2011,40(3):110-114 |
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| 中文摘要:目的研究孕妇感染甲型H1N1流感的临床特点、治疗方法和妊娠结局。方法对杭州市第一人民医院2009年11月1日~12月31日收治的12例甲型H1N1流感孕妇的临床表现、实验室指标、治疗方法及妊娠结局进行回顾性分析，比较甲型H1N1流感孕妇（组1）、非孕妇（组2）与未感染甲型H1N1流感的正常孕妇（组3）临床特征的差异。结果甲型H1N1流感孕妇以发热为最常见症状。3例流感孕妇出现低钾血症。流感孕妇外周血中性粒细胞比例和尿素氮与非孕妇相比差异有统计学意义（P＜0.01）。流感孕妇超敏C反应蛋白、血钾、乳酸脱氢酶和尿素氮与正常孕妇相比差异有统计学意义（P＜0.01）。8例流感孕妇使用奥司他韦治疗，10例孕妇使用抗生素治疗，5例孕妇使用糖皮质激素治疗。5例流感孕妇住院期间终止妊娠，7例孕妇治愈出院后继续妊娠，随访24~27周，无孕妇死亡及严重并发症发生。新生儿随访2~27周，除1例3胎妊娠出生后1胎死亡，其余生长发育情况均良好。结论孕妇感染甲型H1N1流感进展快，较易发展为重症病例，积极住院治疗后可以痊愈。重症甲型H1N1未足月孕妇，经有效治疗后可继续妊娠至近足月，最大限度地减少围生儿死亡和并发症的发生。 |
| 中文关键词:甲型H1N1流感 妊娠 妊娠结局 |
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| Influenza in Pregnancy: Clinical Features and Pregnancy Outcome |
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| Abstract:ObjectiveTo study the clinical features, treatment and pregnancy outcome of H1N1 influenza in pregnancy. MethodsFrom November 1st to December 31st of 2009, 12 cases of pregnant women suffered from H1N1 influenza were admitted to Hangzhou First People′s Hospital. Clinical manifestation, results of laboratory examination, treatment and pregnancy outcome were analyzed retrospectively. Clinical features among pregnant women (group 1), non-pregnant women (group 2), and non-H1N1 influenza infected gravida (group 3) were compared. ResultsFever appeared most frequently in pregnant women who infected H1N1 influenza. Three cases of pregnant women suffered from hypopotassaemia. Significant difference (P＜0.01) was discovered when compared pregnant to non-pregnant women infected H1N1 influenza in neutrophil ratio, lactate dehydrogenase, creatinine and urea nitrogen. Significant difference (P＜0.01) was discovered when compared pregnant women infected H1N1 influenza to nomal pregnant women in C reactive protein, potassium, lactate dehydrogenase and urea nitrogen. Eight cases of pregnant women received Oseltamivir. Ten cases took antibiotics and 5 cases took glucocorticoid. Five cases of pregnant women delivered in hospital and 7 cases continued pregnant post discharge. No death or severe complication was observed during a follow up of 24~27 weeks. All newborn infants were in good health during a follow up of 2~27 weeks, except for one death after birth of triplet pregnancy. ConclusionPregnant women suffered from H1N1 influenza are easier to become severe cases, and can be cured after hospitalization. After effective treatment, preterm pregnant women surffered from severe H1N1 influenza continues pregnant to nearly full term,which minimizes perinatal mortality and complication. |
| keywords:H1N1 influenza Pregnancy Pregnancy outcome |
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