| 成人麻疹T淋巴细胞和血清酶学的检测及意义 |
| 投稿时间：2010-08-13 点此下载全文 |
| 引用本文：王莹,徐爱芳,陈刚,李宏波,章松平.成人麻疹T淋巴细胞和血清酶学的检测及意义[J].医学研究杂志,2011,40(3):120-122 |
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| 中文摘要:目的研究成人麻疹患者外周血T淋巴细胞和血清酶学的变化，探讨其临床意义。方法采集外周血细胞，用标记荧光的抗体进行染色，流式细胞仪检测219例成人麻疹患者和42例健康体检者的T淋巴细胞和NK细胞。同时生化分析仪检测血清酶学（ALT、AST、LDH、CK及CKMB）。结果麻疹组血清酶学（ALT、AST、LDH、CK和CKMB）均明显高于对照组，同对照组比，差异均有统计学意义。麻疹病毒高活性组LDH明显高于低活性组，差异均有统计学意义。与对照组比，麻疹组CD4细胞百分比及CD4/CD8比值均显著降低；CD8细胞百分比和NK细胞百分比均显著升高，差异均有统计学意义。麻疹病毒高活性组T淋巴细胞和NK细胞百分比与麻疹病毒低活性组比，差异均无统计学意义(P>0.05)。 结论测定成人麻疹患者外周血T淋巴细胞和血清酶学的变化，有助于评价麻疹病毒感染的机体免疫状况，对预示疾病进展和临床疗效评价具有重要参考价值。 |
| 中文关键词:麻疹 T淋巴细胞 转氨酶类 乳酸脱氢酶 肌酸激酶 |
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| Study on the Changes of the T-lymphocyte and Plasma Enzymology in Adult Measles |
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| Abstract:ObjectiveTo study the changes of T-lymphocyte and plasma enzymology in adult measles, and to investigate the clinical significance. MethodsPeripheral blood cells were stained with antibodies labled with fluorescecse and T-lymphocytes and NK cells were counted with flow cytometry in all patients(n=219) and normal controls. While the lerels of ALT,AST,LDH,CK and CKMB were detected with chemistry analyzer. ResultsCompared with the control group, the levels of ALT,AST,LDH,CK and CKMB in patients with measles-infection were significantly increased. The levels of LDH in high-activity group were significantly higher than those of the low-activity group.Compared with the control group, the percentage of CD4 and CD4/CD8 in patients with measles-infection was significantly decreased,and the percentage of CD8 and NK cells in patients with measles-infection was significantly increased. While there was no difference in the counts of the T-lymphocyte and NK cells between high-activity groups and low-activity groups(P>0.05). ConclusionTo understand the changes of T-lymphocyte and plasma enzymology in adult measles may not only help to evaluate the patients′ cellular immune status, but also be of great values in predicting the replication of measles. |
| keywords:Measles T-lymphocyte ALT AST LDH CK |
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