| 舌下变应原特异性免疫疗法对儿童过敏性哮喘临床疗效及肺功能的影响 |
| 投稿时间：2010-12-24 点此下载全文 |
| 引用本文：姜毅,李温慈,徐海滨,邵山鹰.舌下变应原特异性免疫疗法对儿童过敏性哮喘临床疗效及肺功能的影响[J].医学研究杂志,2011,40(6):85-88 |
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| 基金项目:温州市科技局资助项目(Y20070119) |
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| 中文摘要:目的探讨舌下变应原特异性免疫疗法对过敏性哮喘患儿临床疗效及肺功能的影响。方法将100例年龄4~7岁过敏性哮喘患儿随机分为粉尘螨治疗组（50例）和对照组（50例），分别给予“粉尘螨滴剂”舌下含服加常规吸入糖皮质激素治疗及单独用吸入糖皮质激素治疗，治疗25周结束。对两组治疗前后的临床疗效及肺功能（IOS）指标进行分析比较。结果两组临床控制率、总有效率相比有明显差异（P<0.05）。对照组治疗后5、20Hz时气道阻力（R5、R20）较治疗前均有降低，治疗前后比较差异均有统计学意义（P＜0.05）；肺弹性阻力(X5) 和共振频率(fres)治疗前后比较差异均无统计学意义（P＞0.05）。粉尘螨治疗组治疗后R5、R20、X5、Fres较治疗前均有降低，治疗前后比较差异均有统计学意义（P＜0.05）。粉尘螨治疗组治疗后较对照组治疗后R5、R20、X5、Fres下降幅度大，两组比较差异均有统计学意义（P＜0.05）。结论舌下变应原特异性免疫疗法治疗儿童过敏性哮喘临床疗效显著，可显著改善过敏性哮喘儿童的肺功能。 |
| 中文关键词:过敏性哮喘 粉尘螨滴剂 儿童 免疫治疗 |
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| Effects of Sublingual Allergen Specific Immunotherapy on Pulmonary Function and Clinical Curative Effect in Children with Allergic Asthma |
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| Abstract:ObjectiveTo investigate the effects of sublingual allergen specific immunotherapy on pulmonary function and clinical curative effect in children with allergic asthma. MethodsWe divided 100 cases with allergic asthma into dust mites therapy group (50 case) and control group (50 cases). Patients in the dust mites therapy group received“Dermatophagoides Farinae drops”sublingual immunotherapy based on regular treatment of inhaled corticosteroids,while cases in control group received regular treatment of inhaled corticosteroids alone. Twenty-five cases in weeks later, we compared clinical effect and lung function(IOS) between both groups. ResultsThere was significant differences between the two groups in clinical controlled rate and efficiency (P<0.05). In the control group，5 and 20Hz airway resistance (R5,R20) decreased after treatment with inhaled corticosteroids，and there was statistically significant difference before and after treatment(P<0.05), while there were no significant difference in pulmonary elastic resistance (X5) and the resonance frequency (Fres) (P >0.05).In the dust mites therapy group,the indexs of R20,R5,Fres,X5 decreased after treatment with sublingual immunotherapy.There was significant difference before and after treatment with sublingual immunotherapy (P<0.05).There was sharply significant difference in R20,R5,Fres,X5 between the dust mites therapy group and control group after treatment (P<0.05). ConclusionSublingual allergen specific immunotherapy has a significant effect in children allergic asthma treatment，which can improve pulmonary function. |
| keywords:Allergic asthma Dermatophagoides farinae drops Children Immunotherapy |
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