| 绝经后妇女应用替勃龙对防治动脉粥样硬化的作用 |
| 投稿时间：2010-11-26 点此下载全文 |
| 引用本文：唐云炳,管玉涛,邱海凡,蔡莲莲,赵智林,黄品同.绝经后妇女应用替勃龙对防治动脉粥样硬化的作用[J].医学研究杂志,2011,40(6):107-109 |
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| 中文摘要:目的通过检测绝经后妇女应用替勃龙后体内性激素、血脂水平，超声检测其颈动脉血管壁，评价绝经后妇女应用替勃龙后对防治动脉粥样硬化的意义。方法对118例绝经后妇女患者，随机分为两组：研究组61例给予替勃龙1.25mg/d，对照组57例不用任何药物，随访1年并检测E2、MMP-9及血脂水平，超声检测颈动脉内膜-中层厚度（IMT）、斑块情况。结果研究组MMP-9、三酰甘油（TG）、总胆固醇(CHO)及低密度脂蛋白(LDL)均低于对照组：4.27±1.33ng/ml vs 7.96±215ng/ml；1.39±0.49mmol/L vs 1.85±0.61mmol/L；4.68±0.63mmol/L vs 5.54±0.77mmol/L；2.61±0.27mmol/L vs 3.38±045mmol/L，而研究组E2 30.33±8.74pg/ml高于对照组15.95±6.09pg/ml，均有统计学意义（P<0.05）；研究组颈动脉IMT平均厚度0.83±0.19mm小于对照组0.98±0.17mm并有统计学意义（P<0.05），研究组不稳定性斑块(软斑块，混合斑块)检出率低于对照组并有统计学意义（5/61 vs 13/57）（P<0.05）。结论使用替勃龙治疗能有效改善血脂水平及血管功能，稳定斑块，有利于防治绝经后妇女的动脉粥样硬化。 |
| 中文关键词:绝经后 替勃龙 颈动脉 动脉粥样硬化 超声 |
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| The significance in Preventing and Treating Atherosclerosis by Using Tibolone in Postmenopausal Women |
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| Abstract:ObjectiveBy testing the E2 level,blood-lidpoids and investigating the ultrasonographic image feature of the carotid artery,to evaluate the significance in preventing and treating atherosclerosis by using tibolone in postmenopausal women.Methods118 cases of healthy postmenopausal women were randomly divided into study group and control group.Cases in the study group (61 cases) were treated with tibolone for 1.25mg/d,and cases in the control group (57 cases) got no treatment.They were followed up for one year and then the the E2,MMP-9 level,blood-lidpoids were detected.The IMT and atherosclerotic lesions of Carotid artery were checked by ultrasound.ResultsThe MMP-9,TG,CHO,LDL levels in study group were obviously lower than those in the control group［4.27±133ng/ml vs 7.96±2.15ng/ml；1.39±0.49mmol/L vs 1.85±0.61mmol/L；4.68±0.63mmol/L vs 5.54±0.77mmol/L；2.61±027mmol/L vs 3.38±0.45mmol/L, (P<0.05)］.E2 in study group (30.33±8.74pg/ml) was obviously higher than that in the control group ［15.95±6.09pg/ml (P<0.05)］.The mean thickness of IMT in study group （0.83±0.19mm) was obviously thinner than the control group ［0.98±0.17mm(P<0.05)］.The ratio of vulnerable carotid atherosclerotic lesions(soft and mixed atherosclerotic lesions) in study group was obviously less than that in the control group（5/61 vs 13/57）(P<0.05).ConclusionUsing tibolone in postmenopausal women can improve the blood-lidpoids and vessel function, stabilize the atherosclerotic lesions,which is helpful for preventing and treating the atherosclerosis. |
| keywords:Postmenopause Tibolone Carotid artery Atherosclerosis Ultrasonography |
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