| 伤后不同时期髓内固定对骨折愈合影响的实验研究 |
| 投稿时间：2010-10-18 修订日期：2011-06-22 点此下载全文 |
| 引用本文：白祥,李晓东,马志新.伤后不同时期髓内固定对骨折愈合影响的实验研究[J].医学研究杂志,2011,40(9):107-110 |
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| 中文摘要:目的探讨伤后不同时期髓内固定对兔胫骨骨折愈合过程的影响。方法清洁剂兔行右侧胫骨中段横形截骨后，随机分为即时固定组（A组）、延迟1周固定组（B组）和延迟2周固定组（C组），均行克氏针（Φ=2.5mm）髓内固定术，术后行X线、组织学及BMP-2免疫组化观察。结果术后1、4周时B、C组和A组间差异有统计学意义（P＜0.05）,B组和C组相比则差异无统计学意义（P＞0.05）；术后2周时3组间差异均有统计学意义（P＜0.05）。结论实验性骨折在一定的时间内延迟切开复位内固定可加速骨折愈合。 |
| 中文关键词:延期手术 内固定 骨折愈合 实验研究 |
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| Effect of Early Versus Delayed Internal Fixation on Fracture Healing |
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| Abstract:ObjectiveTo detect the effect of early versus delayed internal fixation on fracture healing.MethodsRabbits with transverse osteotomy of middle diaphyses of right tibial were divided randomly into three groups：group A (immediate internal fixation on the day of injury),group B（delayed internal fixation at the end of the first week） and group C(delayed internal fixation at the end of the second week).All fractures were immobilized with a 2.5mm-diameter kirsehner wire as intramedullary nail.The X-ray films,histological and immunohistochemical sections were made for the evaluation of effects on fracture healing after internal fixation.ResultsThere was a significant difference between group B or C and A(P<0.05),not a significant difference between group B and C(P>0.05) at 1,4 weeks after internal fixation.There was a significant difference among group A,B and C (P<0.05) at 2 weeks after internal fixation.ConclusionIt is beneficial to the healing of fracture that open reduction and internal fixation of the closed tibial fracture is delayed in a limited time. |
| keywords:Delayed operation Internal fixation Fracture healing Experimental study |
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