| cPSAD在汉族人群PSA灰区前列腺癌早期筛查中的应用研究 |
| 投稿时间：2011-03-20 修订日期：2011-03-30 点此下载全文 |
| 引用本文：王于勇,于志坚,俞蔚文,廖国栋,王刚,郑祥毅,王兵,何翔,何华东,潘毓鸣.cPSAD在汉族人群PSA灰区前列腺癌早期筛查中的应用研究[J].医学研究杂志,2011,40(11):75-78 |
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| 基金项目:2009年浙江省医药卫生科技计划项目(2009A161) |
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| 中文摘要:目的研究cPSAD在汉族人群PSA灰区前列腺癌早期筛查中的应用价值。方法2002年1月~2010年12月收集了265例PSA水平介于4~10ng/ml并接受前列腺穿刺活检的患者，通过接收者工作特征曲线（ROC）分析法评价PSA值、f/tPSA值、PSAD值和cPSAD值在预测诊断前列腺癌中的敏感性和特异性，寻找敏感性和特异性较好的前列腺癌早期预测指标。结果265例患者中，63例为前列癌患者，占23.77%。PSA、cPSA、PSAD、t/fPSA、cPSAD 5个参数的ROC曲线下面积分别为：0603、0.706、0.865、0.800、0.875，在所有参数中，cPSAD的AUC最大，较其他参数有更高的诊断效率。cPSAD取截点为00970ng/ml2时可达到90%的敏感度和63.4%的特异度，取截点为0.1296ng/ml2时可达到85%的敏感度和78.7%的特异度。结论在汉族人群PSA灰区前列腺癌早期筛查诊断中，cPSAD较其他目前常用的PSA相关指标更具优势。 |
| 中文关键词:cPSAD 前列腺癌 PSA PSA灰区 |
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| The Utility of Complexed Prostate Specific Antigen Density （cPSAD） for Early Detection Proatate Cancer in Han Population with Different Serum PSA Levels |
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| Abstract:ObjectiveTo investigate the utility of cPSAD for early detection proatate cancer in Han population with serum PSA levels of 4~10ng/ml. MethodsForm January 2002 to December 2010,265 men with total PSA levels of 4~10ng/ml participated in a protocol for prostate-cancer screening,and eligible patients were recommended for prostate biospies. The diagnostic value of PSA,cPSA,PSAD,the free-to-total PSA ratio (f/tPSA) and cPSAD were compared using receiver operating characteristic(ROC) analysis. ResultsProstate cancer was diagnosed in 63(23.77%) of the 265 men.The area under the curve(AUC) of PSA,cPSA,PSAD,t/fPSA and cPSAD were 0.603,0.706,0.865,0.800 and 0.875 respectively.The AUC of cPSAD was the largest in all of the PSA-related indicators,and cPSAD was the best indicator of prostate cancer. The sensitivity and specificity of cPSAD at a cutoff of 0.0970ng/ml2 was 90.0%, 634% respectively,and the sensitivity and specificity of cPSAD at a cutoff of 0.1296ng/ml2 was 85%, 78.7% respectively. ConclusioncPSAD was better than the other PSA derivatives for early dectection prostate cancer in Han population with serum PSA levels of 4~10ng/ml. |
| keywords:Complexed prostate specific antigen density Prostate cancer Prostate specific antigen PSA gray |
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