| 维持性血液透析患者血浆血管细胞黏附分子-1的变化和意义 |
| 投稿时间：2011-04-08 修订日期：2011-05-03 点此下载全文 |
| 引用本文：姜立萍,黄雯.维持性血液透析患者血浆血管细胞黏附分子-1的变化和意义[J].医学研究杂志,2012,41(2):45-47 |
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| 中文摘要:目的探讨尿毒症维持性血液透析（MHD）患者血浆可溶性血管细胞黏附分子-1（sVCAM-1）的变化及其意义。方法应用酶联免疫吸附试验(ELISA)法测定48例尿毒症维持性血液透析患者（MHD组）和20例健康志愿者(对照组)血浆sVCAM-1、CRP和sCD40L的水平。 结果MHD组血浆sVCAM-1、CRP和sCD40L的水平均明显高于对照组（P＜0.01），MHD伴冠心病组sVCAM-1、CRP和sCD40L水平明显高于不伴冠心病组（P＜0.01）；直线相关分析表明sVCAM-1水平与CRP呈正相关（r=0.413,P＜0.01），与sCD40L呈正相关(r=0.368,P＜0.05)。结论MHD患者尤其是合并冠心病患者sVCAM -1的水平升高，可能参与动脉粥样硬化的形成。 |
| 中文关键词:血液透析 冠心病 血管细胞黏附分子-1 C反应蛋白 CD40配体 |
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| Changes of Plasma Soluble Vascular Cell Adhesion Molecule-1 in Uremic Patients with Maintenance Hemodialysis and Its Significance |
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| Abstract:ObjectiveTo investigate the changes of plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) and its significance in uremic patients undergoing maintenance hemodialysis (MHD). MethodsEnzyme-linked Immunosorbent Assay was used to measure the plasma sVCAM-1,CRP and sCD40L in maintenance hemodialysis patients (MHD group, n=48) and healthy volunteers (control group, n=22). ResultsThe levels of sVCAM-1,CRP and sCD40L were significantly higher in MHD patients than those in control (P<0.01),and the levels of sVCAM-1,CRP and sCD40L were also higher in MHD patients with coronary heart disease(CHD) than those without CHD (P<0.01). The linear correlation analysis showed that sVCAM-1 level was positively related to CRP (r=0413, P＜0.01) and sCD40L (r=0.368, P＜0.05). ConclusionThe elevated levels of sVCAM-1 in MHD patients, particularly in those with CHD，suggested the possible relation to the pathogenesis of atherosclerosis. |
| keywords:Hemodialysis Coronary heart disease Vascular cell adhesion molecule-1 C-reactive protein CD40 ligand |
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