| 扩张型心肌病心力衰竭患者血清BNP水平与心室重构的相关性研究 |
| 投稿时间：2011-07-31 修订日期：2011-09-06 点此下载全文 |
| 引用本文：孙婷,周静,陈祥华,汤政德,金雅琴.扩张型心肌病心力衰竭患者血清BNP水平与心室重构的相关性研究[J].医学研究杂志,2012,41(4):62-64 |
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| 基金项目:上海交通大学医学院附属第九人民医院基金资助课题（JY2011B12） |
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| 中文摘要:目的探讨扩张型心肌病心力衰竭患者血浆脑钠素（BNP）水平与心室重构指标的相关性。 方法入选2010年7月～2011年7月在上海交通大学医学院附属第九人民医院心内科住院治疗的53例扩张型心肌病患者，美国纽约心脏病学会（NYHA）心功能分级为Ⅲ级或Ⅳ级，免疫荧光法测定BNP值，超声测量心室重构指标，包括各房室大小、室间隔及左心室后壁厚度，左心室射血分数，采用Pearson相关分析比较各指标的相关性。 结果NYHA Ⅳ组血清BNP水平与NYHA Ⅲ组比较明显增高 (t=2.896, P<0.01)，BNP水平与左心室射血分数负相关( n=53,r=-0.576, P<0.01)、与心肌扩张度呈正相关( n=53, r=0.527, P<0.01), 与室间隔厚度负相关(n=53,r=-0.413, P<0.01)，与左心室后壁厚度负相关( n=53,r=-0.351, P<005)。 结论扩张性心肌病心力衰竭患者血清BNP水平不仅能预测心功能分级，而且能反映患者心室重构的程度，可预测心肌病心力衰竭的发生发展的程度。 |
| 中文关键词:扩张型心肌病 心力衰竭 心室重构 脑钠素 |
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| Relationship between Brain Natriuretic Peptide and Left Ventricular Remodeling in Patients with Heart Failure Secondary to Dilated Cardiomyopathy |
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| Abstract:ObjectiveTo analyse the character and relationship of brain natriuretic peptide (BNP) and left ventricular remodeling in heart failure (HF) secondary to dilated cardiomyopathy (DCM). MethodsA total of 53 patients with DCM (NYHA class Ⅲ or Ⅳ heart failure), seen at Shanghai Ninth People′s Hospital from July 2010 to July 2011, formed the study. The plasma BNP level was measured using the microparticle enzyme immunoassay test. The parameters, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness at diastole(IVSd), left ventricular posterior wall dimensions (LVPWD) were examined by an ultrasound system. The correlations with echo doppler parameters and plasma BNP levels were performed using Pearson′s correlations. ResultThe plasma BNP level was higher in NYHA class Ⅳ groups than in NYHA class Ⅲ groups (t=2.896, P<0.01). The plasma BNP level correlated well with LVEF (r=-0.576, P<0.01), LVEDD (r=0.527, P<0.01), IVSd (r=-0.413, P<0.01), LVPWD (r=-0.351, P<0.05). ConclusionThe plasma BNP level was not only predictive of the grade of HF, but also reflective of the degree of left ventricular remodeling in DCM patients, which had predictability for the progression of DCM to HF. |
| keywords:Dilated cardiomyopathy Heart failure Ventricular remodeling Brain natriuretic peptide |
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