| 正常中脑导水管脑脊液流动与年龄相关性研究 |
| 投稿时间：2011-06-30 修订日期：2011-07-11 点此下载全文 |
| 引用本文：胡卫东,项立,张宏光,高天俊,王秀荣.正常中脑导水管脑脊液流动与年龄相关性研究[J].医学研究杂志,2012,41(5):83-85 |
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| 基金项目:深圳市龙岗区科技计划基金资助项目（YW2007044, YLL2010064） |
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| 中文摘要:目的对正常女性中脑导水管层面脑脊液（cerebralspinal fluid,CSF）的流动情况进行磁共振（magnetic resonance imaging,MRI）定量研究并将其与年龄进行回归分析。方法筛选38例正常女性志愿者，测量其中脑导水管CSF流动情况，以年龄作为因变量，流速（收缩期向下最大流速V1,舒张期向上最大流速V2、平均向下流速V3、平均向上流速V4及平均流速V5）、流量（收缩期向下最大流量Q1、舒张期向上最大流量Q2、平均向下流量Q3、平均向上流量Q4、平均流量Q5、平均净流量Q6） 及心动周期（收缩期向下最大流速对应心动周期T1、舒张期向上最大流速对应心动周期T2、平均心动周期T3）作为自变量进行线性回归分析。结果一般回归方程分别为age=38.146+0.825V1+0.705V2-0.738V3-0.298V4-0.887V5，age=46899-117944Q1+21.319Q2-191.968Q3+62.774Q4-84.361Q5-227.401Q6，age=36.047+0.063T1+0.016T2+0.010T3。各项指标P均>0.05，无显著性差异。结论自变量流速、流量及心动周期3者对因变量年龄无显著性影响。在应用MR定量分析CSF流速、流量及心动周期时无需考虑年龄因素。 |
| 中文关键词:脑脊液 导水管 磁共振成像 年龄因素 回归分析 |
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| Abstract:ObjectiveTo quantitatively study the features of cerebrospinal fluid flow dynamics in normal aqueduct cerebrospinal of normal female volunteers by MRI and go regression analysis of them with age. MethodsTotally 38 cases of normal female volunteers were screened.The aqueduct cerebrospinal flow of CSF was measared age as the dependent variable, velocity（the out and in flow peak velocity and mean out and in velocity(V1:the max velocity of systolic, V2:the max velocity of diastole, V3:the mean velocity of systolic, V4:the mean velocity of diastole, V5:average velocity),flows(Q1:the max flow of systolic, Q2:the max flow of diastole, Q3:the max flow of diastole, Q4:the mean flow of diastole, Q5:average flow, Q6:the average net flow),value of cardiac cycle(T1:the correspond cardiac cycle of max velocity of systolic, T2:the correspond cardiac cycle of max velocity of diastole, T3:average cardiac cycle) in a cardiac cycle as independent variables for linear regression analysis was carried out.ResultsGeneral regression equations were：age=38.146+0825V1+0705V2-0.738V3-0.298V4-0.887V5，age=46.899-117.944Q1+21.319Q2-191.968Q3+62.774Q4-84.361Q5-227401Q6，age=36.047+0.063T1+0.016T2+0.010T3. We can obtain three linear regression line diagrams and three histograms. There was no significant difference between dependent variable and independent variables (P>0.05). ConclusionWe need not consider the age factor because of no significant difference between dependent variable and independent variables when MR in the application of quantitative analysis of CSF velocity, flows and value of cardiac cycle. |
| keywords:Cerebralspinal fluid（CSF） Aqueduct Magnetic resonance imaging Age factors Regression analysis |
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