| 2型糖尿病合并不稳定性心绞痛患者尿微量白蛋白、血浆内皮素与冠脉病变程度的关系研究 |
| 投稿时间：2011-08-17 修订日期：2011-09-14 点此下载全文 |
| 引用本文：郑巨克,李星群,潘嘉西,章敏学.2型糖尿病合并不稳定性心绞痛患者尿微量白蛋白、血浆内皮素与冠脉病变程度的关系研究[J].医学研究杂志,2012,41(5):153-155 |
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| 中文摘要:目的探讨2型糖尿病合并不稳定性心绞痛患者尿微量白蛋白（MA）和血浆内皮素（ET）与冠脉病变程度的关系。方法通过将笔者医院2009年1 月~2011年1月住院治疗的85例不稳定性心绞痛患者依据冠脉病变支数和Gensini 积分进行分组，并分析MA 和ET与冠脉病变支数及Gensini 积分相关性。结果①多支病变组（≥2支）共有69例患者，占81.2%，单支病变组16例患者，占18.8%；严重病变组（即Gensini积分﹥20分）共有53例患者，占62.4%，非严重病变组（即Gensini积分0~20分）32例患者，占37.6%;②单支病变组的ET水平（72.32±7.34pg/ml vs 81.47±5.65pg/ml,P<0.05）和MA水平（23.46±1.15mg/L vs 35.21±4.23mg/L,P<0.01）均低于多支病变组，非严重病变组的ET水平和MA水平均低于严重病变组（P<001和P<0.05）;③2型糖尿病合并不稳定性心绞痛患者ET水平和MA水平与Gensini 积分具有显著相关性（r=0.75,P<0.05和r=0.63,P< 0.05）。结论2型糖尿病合并不稳定性心绞痛患者的尿微量白蛋白和血浆内皮素与冠脉病变程度有显著性的正相关，随着冠脉病变程度的加重，其尿微量白蛋白和血浆内皮素的水平升高。 |
| 中文关键词:2型糖尿病 尿微量白蛋白 血浆内皮素 冠脉病变程度 Gensini积分 |
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| Relationship Between Microalbuminuria and Plasma Endothelin and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus Angina |
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| Abstract:ObjectiveTo explore the relationship between microalbuminuria (MA) and endothelin (ET) and degree of coronary stenosis in patients with type 2 diabetes mellitus and unstable angina. MethodsTotally 85 patients treated in our hospital from January 2009 to January 2011 were divided into groups according to the number of coronary vessels disease and coronary Gensini score. Then, the relevance between level of MA and ET with the number of coronary vessels disease and coronary Gensini score was analyzed. Results(1) There were 69 patients (81.2%) in multi-vessel stenosis group and 16 patients (18.8%) in one-vessel stenosis group. Meanwhile, there were 53 patients (62.4%) in advanced lesions group（Gensini Score﹥20） and 32 patients (37.6%) in non-advanced lesions group(Gensini Score 0-20). (2) The ET (72.32±7.34pg/ml vs 81.47±5.65 pg/ml,P<0.05) and MA (23.46±1.15mg/L vs 35.21±4.23 mg/L, P< 0.01) level of one-vessel stenosis group were lower than the multi-vessel stenosis group with a significant difference. The ET (P<0.01) and MA (P<0.05) level of non-advanced lesions group were lower than advanced lesions group.(3) There were significant relevance between ET (r=0.75, P<0.05) and MA (r=0.63,P<0.05) level with Gensini score in patients with type 2 diabetes mellitus and unstable angina. ConclusionThere was significant relevance between ET and MA level with severity of coronary artery disease in patients with type 2 diabetes mellitus and unstable angina. With the development of severity of coronary artery disease, the ET and MA level elevated. |
| keywords:Type 2 diabetes mellitus Microalbuminuria Endothelin Severity of coronary artery disease Gensini score |
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