| GRP78和Mn-SOD表达与鼻咽癌组织放疗敏感相关性研究 |
| 投稿时间：2014-07-21 修订日期：2014-09-09 点此下载全文 |
| 引用本文：邓香群,彭波.GRP78和Mn-SOD表达与鼻咽癌组织放疗敏感相关性研究[J].医学研究杂志,2015,44(3):85-88,100 |
| DOI：
10.3969/j.issn.1673-548X.2015.03.024 |
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| 基金项目:湖南省科技厅科技计划项目(2011FJ4141) |
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| 中文摘要:目的 研究GRP78、Mn-SOD mRNA在放射治疗鼻咽癌中的表达, 探讨其在放射治疗鼻咽癌中的意义。方法 取60例2006年1月13日~11月26日第1次入院放射治疗鼻咽癌, 运用原位杂交方法检测放射治疗鼻咽癌中GRP78及Mn-SOD mRNA的表达。结果 在放疗敏感及放疗抗拒鼻咽癌患者中, GRP78 mRNA中度和强阳性表达率分别为20.00%和47.50%, Mn-SOD mRNA中度和强阳性表达率分别为55.00%和40.00%, 差异有统计学意义。在放疗抗拒鼻咽癌患者中, GRP78 mRNA中度和强阳性表达率与TNM分期呈正相关, Ⅲ~Ⅳ期GRP78 mRNA中度和强阳性表达率为58.62%, Ⅰ~Ⅱ期表达率为18.18%, 与T分期呈正相关, T3~T4期中表达率为68.42%, T1~T2期中表达率为28.57%;Mn-SOD mRNA中度和强阳性表达率与T分期呈正相关, T3~T4期中表达率为63.16%, T1~T2期中表达率为19.05%;在有、无远处转移中, GRP78 mRNA中度和强阳性表达率分别为72.73%和37.93%, Mn-SOD mRNA中度和强阳性表达率分别为81.82%和24.14%, 差异有统计学意义(P<0.05)。结论 GRP78、Mn-SOD参与了放疗抗拒鼻咽癌的发展。 |
| 中文关键词:GRP78基因 Mn-SOD基因 放射治疗 鼻咽癌 |
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| Relative Expressions of GRP78 and Mn-SOD in Radiotherapy of Nasopharyngeal Carcinoma |
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| Abstract:Objective To study the expressions of GRP78 and Mn-SOD in the radiotherapy of nasopharyngeal carcinoma, as well as their significances. Methods Radiotherapies were taken in 60 cases of nasopharyngeal carcinoma from 2006.1.13-2006.11.26 in situ hybridization detections were carried out to detect the expression of GRP78 and Mn-SOD mRNA. Results In radiosensitivity and radioresistance of nasopharyngeal carcinoma, the moderately and strongly positive GRP78 mRNA expression rates were 20.00% and 47.50%, the moderately and strongly positive Mn-SOD mRNA expression rates were 55.00% and 40.00%, and the differences were statistical significance. In the radioresistance of nasopharyngeal carcinoma, GRP78 mRNA moderately and strongly positive expression was positively correlated with TNM stage. In the degree of Ⅲ-Ⅳ, it had moderately and strongly positive expression rate of 58.62%. In the degree of Ⅰ-Ⅱ, it had moderately and strongly positive expression rate of 18.18%, and it was also positively correlated with T stage. In the degree of T3-T4, it had moderately and strongly positive expression rate of 68.42%. In the degree of T1-T2, it had moderately and strongly positive expression rate of 28.57%. Mn-SOD mRNA moderately and strongly positive expression was positively correlated with T stage.In the degree of T3-T4, it had moderately and strongly positive expression rate of 63.16%. In the degree of T1-T2, it had moderately and strongly positive expression rate of 19.05%. In distant metastasis and no distant metastasis, the moderately and strongly positive GRP78 mRNA expression rates were 72.73% and 37.93%, the moderately and strongly positive Mn-SOD mRNA expression rates were 81.82% and 24.14%, and the differences had statistical significance. Conclusion GRP78 and Mn-SOD have participated in the development of radioresistant nasopharyngeal carcinoma. |
| keywords:GRP78 gene Mn-SOD gene Radiotherapy Nasopharyngeal carcinoma |
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