| 桂红胶囊抗心肌缺血实验研究 |
| 投稿时间：2014-11-14 修订日期：2014-11-27 点此下载全文 |
| 引用本文：石仲歌,孙明江,任赵燕,孙晓伟.桂红胶囊抗心肌缺血实验研究[J].医学研究杂志,2015,44(6):97-99 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.027 |
| 摘要点击次数: 1633 |
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| 基金项目:山东省博士后创新基金资助项目(115480);济南市科技计划项目(201202043) |
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| 中文摘要:目的 研究桂红胶囊对缺血心肌的保护作用。方法 采用小鼠常压耐缺氧实验及垂体后叶素(Pit)致大鼠急性心肌缺血模型,观察桂红胶囊对缺血心肌的保护作用。结果 桂红胶囊(0.278、0.555、1.110g/kg)均能显著延长小鼠常压耐缺氧条件下的存活时间,桂红胶囊(0.140、0.278、0.556g/kg)能拮抗Pit引起的心电图变化。结论 桂红胶囊对缺血心肌具有保护作用。 |
| 中文关键词:桂红胶囊 心肌缺血 药理研究 |
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| Experimental Study of Guihong Capsule on Myocardial Ischemia |
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| Abstract:Objective To study the protective effects of Guihong capsule against myocardial ischemia in rats. Methods The protective effects of Guihong capsule against myocardial ischemia were observed in mice by recording their survival time under closed normobaric hypoxia and in SD rats with myocardial ischemia induced by pituitrin(Pit)injection. Results Guihong capsule(0.278,0.555,1.110 g/kg)could significantly prolonged the survival time of mice under closed normobaric hypoxia. At 0.140,0.278 and 0.556 g/kg,Guihong capsule could significantly antagonized pituitrin-induced ECG changes. Conclusion Guihong capsule may offer protection against myocardial ischemia in animal models. |
| keywords:Guihong capsule Myocardial ischemia Pharmacological research |
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