| 胃癌组织中Her-2、VEGF-C的表达及意义 |
| 投稿时间：2014-10-21 修订日期：2014-11-18 点此下载全文 |
| 引用本文：王哲近,麻忠武,陈峰,潘步建,徐迈宇,金肖丹.胃癌组织中Her-2、VEGF-C的表达及意义[J].医学研究杂志,2015,44(6):130-133 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.037 |
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| 中文摘要:目的 检测表皮生长因子受体2(HER-2)、血管内皮生长因子C(VEGF-C)在胃癌组织中的表达,并分析结果与临床病理之间的关系。方法 选取50例胃癌组织及20例癌旁正常胃组织标本,采用免疫组化方法检测HER-2、VEGF-C的表达,并分析其表达情况及临床参数之间的关系。结果 50例胃癌组织中HER-2、VEGF-C蛋白的阳性表达率为38%(19/50)、48%(24/50);在胃正常组织中均无表达;HER-2、VEGF-C蛋白表达与患者的性别、年龄、肿瘤部位、肿瘤直径、分化程度差异均无统计学意义(P>0.05);而与肿瘤浸润深度、TNM分期、淋巴结转移、远处转移差异有统计学意义(P<0.05);HER-2与VEGF-C在胃癌组织中的表达呈正相关(rs=0.353,P<0.05)。结论 HER-2、VEGF-C在胃癌组织中均存在表达,两者与肿瘤的浸润与转移密切相关。 |
| 中文关键词:胃癌 表皮生长因子受体2 血管内皮生长因子C |
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| Expression and Significance of Her-2 and VEGF-C in Human Gastric Carcinoma Tissues |
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| Abstract:Objective To determine the expression of human epidermalgrowth factor receptor-2(HER-2) and vascular endothelial growth factor C(VEGF-C) in gastric carcinoma tissues, and analyze the results and the relationship with clinical pathologic. Methods Immunohistochemical method was performed to detect the expressions of HER-2 and VEGF-C in 50 samples of gastric carcinoma tissues and 20 samples of normal gastric mucosal tissues.Then we analyzed their relationships with clinicopathologic parameters. Results The positive rate of HER-2, VEGF-C in the 50 cases primary gastric cancer tissues were 38%(19/50) and 48%(24/50), However, the expression of HER-2, VEGF-C was not found in nearby gastric tissues. No correlation was found between expression levels of HER-2 and VEGF-C in gastric carcinoma tissues with sexes, ages, tumor locations, size, differentiation type. The positive expression rate of HER-2 and VEGF-C was correlated to depth of invasion,TNM stage,lymph node metastasis and distant metastasis of gastric cancer patients (P<0.05)。In gastric carcinoma tissues, the expression of HER-2 and VEGF-C have positive correlation(rs=0.353,P<0.05). Conclusion Expression of HER-2, VEGF-C was observed in gastric cancer. Both of them correlate with the presence of cancer invasion and metastasis. |
| keywords:Gastric cancer Epidermal growth factor 2 Vascular endothelial growth factor-C |
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