| 狂犬病疫苗2-1-1方案的初种与复种效果的动态观察 |
| 投稿时间：2014-12-04 修订日期：2014-12-27 点此下载全文 |
| 引用本文：蒋学友,张建,郑以山,王念跃,仲崇辉.狂犬病疫苗2-1-1方案的初种与复种效果的动态观察[J].医学研究杂志,2015,44(7):80-83 |
| DOI：
10.11969/j.issn.1673-548X.2015.07.023 |
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| 基金项目:江苏省卫生厅科研基金资助项目(Y2012075) |
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| 中文摘要:目的 观察狂犬病疫苗2-1-1接种方案的初种与复种免疫效果。方法 根据3年以前有无狂犬病疫苗接种史分两组进行实验研究:A组:无既往狂犬病疫苗接种史的2-1-1方案初种组;B组:有既往史的2-1-1方案复种组。观察指标包括狂犬病疫苗抗体效价和阳性率。结果 复种组人群在7、21天时狂犬病疫苗抗体效价和阳性率方面均高于初种组,差异有统计学意义。45天时两组间狂犬病疫苗抗体效价有统计学差异,但是阳性率差异无统计学意义。结论 狂犬病疫苗复种组的免疫效果明显优于初种组,复种者早期(7天)即可出现有效浓度的抗狂犬病抗体,因此从事狂犬病高暴露风险者接受暴露前免疫是非常必要的。 |
| 中文关键词:狂犬病疫苗 免疫效果 分析 实验研究 |
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| Dynamic Observation on First-immunization and Re-immunization Effects of Rabies Vaccine 2-1-1 Regimen |
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| Abstract:Objective To observe first-immunization and re-immunization effects of rabies vaccine 2-1-1 regimen.Methods According to the the past history of rabies vaccine inoculation before three years,the volunteers were divided into two groups for experimental research:groupA first-immunization of 2-1-1 regimen without past history of rabies vaccine,groupB re-immunization of 2-1-1 regimen with past history of rabies vaccine.The observation indexes included rabies neutralizing antibodies titer and positive rate.Results The rabies neutralizing antibodies titer and positive rate in group B were both statistically higher than those in group A on 7th and 21st day. There was statistical difference in rabies neutralizing antibodies titer, but wasn't statistical difference in positive rate positive between group A and group B on 45th day. Conclusion The re-immunization effect of rabies was significantly better than the first-immunization effect. The effective rabies neutralizing antibodies titer occurred earlier on 7th day in Re-immunization,so it was quite necessary to receive pre-exposure vaccination for the people engaged in the work with high exposure to rabies risk. |
| keywords:Rabies vaccine Immunization effect Analysis Experimental research |
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