| 高级别岛叶胶质瘤的外科治疗策略 |
| 投稿时间：2015-02-27 修订日期：2015-03-09 点此下载全文 |
| 引用本文：晋强,江涛,王德江.高级别岛叶胶质瘤的外科治疗策略[J].医学研究杂志,2015,44(12):38-41 |
| DOI：
10.11969/j.issn.1673-548X.2015.12.011 |
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| 基金项目:国家自然科学基金资助项目(81072080) |
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| 中文摘要:目的探讨高级别岛叶胶质瘤的外科治疗策略。方法回顾性分析笔者科室自2009年12月~2012年12月收治的18例高级别岛叶胶质瘤。结果18例患者就诊时16例出现中枢神经系统损伤症状,4例出现癫痫发作。本组病例均采用翼点入路切除肿瘤,其中全切7例,近全切除9例,大部切除2例。术后病理证实,18例均为高级别胶质瘤(间变星形细胞瘤至胶质母细胞瘤,WHO Ⅲ~Ⅳ级)。所有患者随访时间24~60个月,平均随访时间40个月,其中死亡8例,存活8例,失访2例;随访到的患者,平均生存期30个月;存活的8例患者,生活均可自理,复查MRI显示,肿瘤无明显复发。结论对于高级别岛叶胶质瘤,临床强调以外科治疗为主的综合治疗。肿瘤全切应以避免造成严重神经功能障碍为前提,对于肿瘤未能全切的患者,术后辅以放/化疗等综合治疗,仍然可以取得比较满意的疗效。 |
| 中文关键词:岛叶 高级别胶质瘤 放疗 化疗 |
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| Strategies of Surgical Treatment for High-grade Insular Gliomas. |
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| Abstract:Objective To discuss the surgical treatment of high-grade insular glioma. Methods A total of 18 patients with high-grade insular gliomas treated at the Beijing Tiantan hospital from December 2009 to December 2012 were reriewed. Results Among the 18 patients, 16 patients showed neurological disorder, 4 patients had a history of seizure. The lateral cleft approach was adopted for the patients. 7 cases achieved gross-total resection, 9 cases achieved subtotal resection, and 2 cases underwent partial resection. All patients were pathologically confirmed with high-grade glioma(WHO Ⅲ-Ⅳ grade), including the anaplastic glioma to the glioblastoma. All patients were followed up for 24~60 months, average 40 months. Eight patients dead,8 patients were still alive,and 2 patients was lost for following up. The follow-up to the patients,the mean survival period is 30 months; 8 patients survived, and their MRI showed no tumor recurrence. Conclusion Comprehensive treatment should be considered for patients with high-grade insular gliomas. Gross total resection should be performed with avoiding of severe neurological disorders. For patients who did not undergo gross total resection, comprehensive treatment such as radiotherapy and chemotherapy should be used to achieve relatively satisfactory results. |
| keywords:Insular High-grade gliomas Radiotherapy Chemotherapy |
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