| 1型糖尿病大鼠肾脏病变与ADPN、TGF-β1、collagen Ⅳ、ICAM-1的关系 |
| 投稿时间：2015-04-30 修订日期：2015-05-19 点此下载全文 |
| 引用本文：郭文荣,李兴,刘晶.1型糖尿病大鼠肾脏病变与ADPN、TGF-β1、collagen Ⅳ、ICAM-1的关系[J].医学研究杂志,2015,44(12):79-82 |
| DOI：
10.11969/j.issn.1673-548X.2015.12.021 |
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| 基金项目:山西省归国留学基金资助项目(2012088) |
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| 中文摘要:目的探讨脂联素、TGF-β1、collagen Ⅳ、ICAM-1在1型糖尿病肾脏病变发生及发展中的变化及作用。方法大鼠随机分为正常对照组和糖尿病组,每组分别于4周和8周,测24h尿白蛋白排泄量(UPro/24h)、空腹血浆葡萄糖、血肌酐、尿素氮、血清脂联素(ADPN)、肾重/体重,观察肾脏TGF-β1、Ⅳ型胶原蛋白(collagen Ⅳ)、ICAM-1的表达。结果糖尿病大鼠UPro/24h增高、TGF-β1、collagen Ⅳ、ICAM-1的表达增加、脂联素水平降低。结论TGF-β1、collagen Ⅳ、ICAM-1在肾脏组织中表达水平与血清ADPN呈负相关。随着ADPN水平降低,TGF-β1、collagen Ⅳ、ICAM-1在肾脏组织的表达增加。 |
| 中文关键词:糖尿病肾脏病变 脂联素 TGF-β1 collagen Ⅳ ICAM-1 |
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| Correlation between Type 1 Diabetic Nephropathy and ADPN,TGF-β1,Collagen Ⅳ,ICAM-1. |
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| Abstract:Objective This study investigated the effect of adiponectin, TGF-β1, collagen Ⅳ, ICAM-1 on development of diabetic nephropathy. Methods Fourty male SD rats were randomly divided into two groups:the normal control group and the diabetic group. At 4 and 8 weeks, 24-hour urinary albumin excretion, fasting plasma glucose(FPG), serum creatinine (Scr), blood urea nitrogen (BUN), kidney weight/body weight, serum adiponectin (ADPN) were measured and determined renal expression of TGF-β1,collagen Ⅳ,ICAM-1. Results 24-Hour urinary albumin excretion and renal expression of TGF-β1,Collagen Ⅳ,ICAM-1 were increased in the diabetic rats. Whereas ADPN were decreased. Conclusion The expression of TGF-β1,collagen Ⅳ,ICAM-1 in renal tissue were negatively correlated with serum ADPN. With the decrease of ADPN, expression of TGF-β1, ICAM-1, collagen Ⅳ increased in kidney tissue. |
| keywords:Diabetic nephropathy Adiponectin TGF-β1 Collagen Ⅳ ICAM-1 |
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