| 高血压脑出血术后高压氧联合依达拉奉治疗对脑血管功能的影响 |
| 投稿时间：2015-06-23 修订日期：2015-06-27 点此下载全文 |
| 引用本文：兰德彬,邹兴军,陈锐.高血压脑出血术后高压氧联合依达拉奉治疗对脑血管功能的影响[J].医学研究杂志,2016,45(1):166-169 |
| DOI：
10.11969/j.issn.1673-548X.2016.01.043 |
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| 中文摘要:目的 探讨高压氧联合依达拉奉对高血压脑出血术后脑血管功能及临床疗效的影响。方法 选取2010年5月~2014年10月在笔者医院住院治疗的130例高血压脑出血术后患者为研究对象,采用数字表法随机分为单纯高压氧组(48例)、单纯依达拉奉组(43例)及联合治疗组(高压氧+依达拉奉,39例)。对各组患者治疗前及治疗后14、28天的脑血流动力学指标、Scandinavian脑卒中量表(Scandinavian stroke scale,SSS)及改良Rankin量表(modified Rankin scale,mRS)评分情况及临床疗效进行比较分析。结果 治疗14、28天后,各组患者脑血管功能均较治疗前有明显改善(P<0.05),但联合治疗组明显优于单纯高压氧及依达拉奉组(P<0.05);治疗14、28天后,各组患者SSS评分较治疗前均显著升高,而mRS评分显著降低(P<0.05),但联合治疗组较单纯高压氧及依达拉奉组,SSS评分升高更明显,mRS评分显著降低(P<0.05);临床疗效分析,高压氧组治疗总有效率为70.8%,依达拉奉组为72.1%,联合治疗组为87.2%。联合治疗组总有效率显著高于高压氧组及依达拉奉组(P<0.05);单纯高压氧治疗后脑血管功能、SSS评分、mRS评分及临床疗效与单纯依达拉奉组比较,差异无统计学意义(P>0.05)。结论 高压氧联合依达拉奉组可显著改善高血压脑出血患者术后脑血管功能及临床疗效,对于降低其病死率及致残率具有重要的临床意义。 |
| 中文关键词:高压氧 依达拉奉 高血压脑出血 脑血管动力学 治疗效果 |
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| Efect of Hyperbaric Oxygen Therapy Combined Edaravone on Cerebrovascular Hemodynamicon in Patients with Hypertensive Cerebral Hemorrhage after Operation |
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| Abstract:Objective To study the effects of the hyperbaric oxygen therapy combined with Edaravone on the cerebrovascular hemodynamics parameters of patients with hypertensive cerebral hemorrhage after the operation. Methods Totally 130 hypertensive cerebral hemorrhage patients were hospitalized from May 2010 to October 2014 and enrolled in this study. Those patients were randomly divided into the hyperbaric oxygen therapy group (48 cases), Edaravone group (43 cases) and combined treatment group (39 cases). The cerebrovascular hemodynamics indexes, Scandinavian Stroke Scale (SSS), modified Rankin scale (mRS), and clinical effects of each groups before and after the treatment at 14 d and 28 d were compared. Results The cerebrovascular hemodynamics indexes after the treatment at 14d and 28d were all significantly better than before (P<0.05). Compared with the hyperbaric oxygen therapy group and Edaravone group, the combined treatment group was better (P<0.05). The SSS scores after the treatment at 14 d and 28 d were all significantly increased than before, but mRS scores were markdly decreased (P<0.05). Compared with the hyperbaric oxygen therapy group and Edaravone group, the SSS scores were increased and mRS scores were decreased in the combined treatment group (P<0.05). Based on clinical effects, the total effective rate in the hyperbaric oxygen therapy group was 70.8%, Edaravone group was 72.1%, the combined treatment group was 87.2%. The total effective rate in combined treatment group was higher than other groups (P<0.05). The cerebrovascular hemodynamics indexes, SSS scores, mRS scores and clinical effects between the hyperbaric oxygen therapy group and Edaravone group had no significant difference (P>0.05). Conclusion The hyperbaric oxygen therapy combined with Edaravone can significantly improve the cerebrovascular hemodynamics and clinical efficacy of cerebral hemorrhage, which plays an important role in reducing the mortality and morbidity. |
| keywords:Hyperbaric oxygen therapy Edaravone Hypertensive cerebral hemorrhage Cerebrovascular hemodynamic Clinical effects |
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