| 不同剂量燕麦β-葡聚糖对大鼠体重及血脂的影响 |
| 投稿时间：2015-12-20 修订日期：2016-01-24 点此下载全文 |
| 引用本文：孙娟,葛声,张海峰,唐雯,刘海丽,张美芳.不同剂量燕麦β-葡聚糖对大鼠体重及血脂的影响[J].医学研究杂志,2016,45(8):66-70 |
| DOI：
10.11969/j.issn.1673-548X.2016.08.018 |
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| 基金项目:上海高校青年教师培养资助计划（ZZjdyx13113） |
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| 中文摘要:目的 研究不同剂量燕麦β-葡聚糖对体重及血脂的影响。方法 雄性SD 大鼠，按体重分层分为5组，每组10 只，分别为正常对照组、高脂对照组、燕麦β-葡聚糖低、中、高剂量组。实验阶段记录进食量并监测体重，连续喂养15周后空腹处死，测定空腹血糖（FBG）、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）及游离脂肪酸（FFA）。取肾周脂肪、肠系膜脂肪以及附睾部脂肪称重。结果 燕麦β-葡聚糖低剂量组每日平均摄入能量显著高于正常对照组及高脂对照组（P<0.01）；空腹体重显著大于正常对照组（P<0.01）；TC高于正常对照组与高脂对照组，分别为P<0.01和P<0.05，LDL显著高于正常对照组与高脂对照组（P<0.01）；肾周脂肪、肠系膜脂肪及腹内总脂肪均显著大于正常对照组（P<0.01），附睾脂肪大于正常对照组（P<0.05）；肾周脂肪、附睾脂肪及肠系膜脂肪均大于高脂对照组（P<0.05），腹内总脂肪显著大于高脂对照组（P<0.01）。燕麦β-葡聚糖高剂量组空腹体重及肠系膜脂肪均小于高脂对照组（P<0.05）。结论 高剂量的燕麦β-葡聚糖可以很好的控制高脂高糖喂养大鼠的体重及肠系膜脂肪含量，低剂量却可以促进其食欲，并增加体重及血清总胆固醇和低密度脂蛋白胆固醇水平。 |
| 中文关键词:燕麦β-葡聚糖 体重 血脂 |
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| Effect of Different Doses of Oat β-Glucans on Body Weight and Serum Lipid in Rats |
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| Abstract:Objective To study the effect of different doses of oat β-glucans on body weight and serum lipid. Methods The rats were divided into 5 groups: Normal control group, High fat feed group, β-glucans LD group,β-glucans MD group and β-glucans HD group. We recorded the food intake and measured the body weight in the experiment. We continuously feed the rats for 15 weeks and killed them. We determined the value of fasting blood glucose (FBG), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and free fatty acid (FFA). We took and weighed the epididymal fat, perirenal fat and mesenteric fat. Results The daily energy intake of the β-glucans LD group were significantly higher than the normal control group and the High fat feed group (P<0.01).The body weight was significantly higher than the normal control group (P<0.01).The TC was higher than the normal control group and the High fat feed group,with P<0.01 and P<0.05 respectively. LDL-C was significantly higher than the normal control group and the High fat feed group (P<0.01). Perirenal fat, mesenteric fat and Peritoneal total fat were significantly higher than the normal control group (P<0.01) and the epididymal fat was higher than the normal control group (P<0.05). Perirenal fat, epididymal fat and mesenteric fat were more than the High fat feed (P<0.05) and peritoneal total fat was significantly more than the High fat feed group (P<0.01). The body weight and mesenteric fat of the β-glucans HD group were less than the High fat feed group (P<0.05). Conclusion The high dose of oat β-glucans can control the body weight and mesenteric fat of the rats that fed with high fat and high sugar foods. But the Low dose of oat β-glucans can promote appetite, increase weight and raise the level of TC and LDL-C. |
| keywords:Oat β-glucans Body weight Serum lipid |
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